Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.

Background: Vestibular migraine (VM) is a disorder characterized by recurrent episodes of dizziness or vertigo and is often accompanied by headache. The mechanisms underlying vestibular dysfunction and pain in VM remain unclear.

Methods: Chronic migraine (CM) and VM models were induced by NTG and kainic acid, respectively.

The Effect of Lamb Vaccination Against Echinococcosis on the Scale of Livestock Farming in Northwestern China.

Echinococcosis (also known as 'hydatidosis' or 'hydatid disease') is a severe zoonotic disease that poses threats to human and animal health and significantly impacts livestock production, which may lead to declines in both the quantity and quality of animal products and result in economic losses. Lamb vaccination against echinococcosis is considered an effective method for controlling the transmission of echinococcosis in the intermediate host-sheep, thereby disrupting the disease's transmission chain, and thus a crucial strategy for preventing and controlling echinococcosis. Based on field survey data on 581 households collected from 11 counties of China's Qinghai Province, this study evaluated the impact of lamb vaccination against echinococcosis on livestock farming scale using a staggered difference-in-differences method.

Multi-dimensional evidence from the UK Biobank shows the impact of diet and macronutrient intake on aging.

Background: The role of diet in aging is crucial, yet research findings on how specific diets influence human aging remain inconsistent. Understanding the relationship between dietary factors and aging could inform interventions to promote healthier aging outcomes.

Methods: We analyzed data from the UK Biobank baseline survey and a 24-hour dietary assessment survey to investigate the association between diet and aging.

Alcohol consumption and allergic diseases: Mendelian randomization evidence from China.

Background: The prevalence of allergic diseases in China has risen significantly over the past decades, affecting the quality of life for approximately 40% of the population.

Objectives: This study aimed to integrate survey and genomic data to explore the potential causal relationship between alcohol consumption and allergic diseases.

Method: In collaboration with a leading genetic testing company in China, we collected data on 3,041 participants via an online survey between December 2018 and October 2019.

One-Step Ethylene Purification from Ternary Mixture through Adaptive Recognition Sites.

One-step adsorptive purification of ethylene (CH) from ternary mixture comprising of acetylene (CH), ethylene (CH) and carbon dioxide (CO) is a great challenge in the chemical industry. Herein, a microporous metal-organic framework (FJI-H38) has been reported, which possesses high-density electronegative O/N binding sites and appropriate pore size. Notably, at 0.

Inspired by plant body frameworks bionics: Fabrication of self-healing polyvinyl alcohol/cellulose nanocrystals composite hydrogels reinforced by polyurethane sponges for flexible supercapacitors.

With the booming development of electronic technology, ultra-toughness and self-healing supercapacitors have drawn substantial attentions. In this work, inspired by plant body frameworks, a novel method was proposed to prepare self-healing conductive hydrogels based on self-healing polyurethane sponge (PUS) network. First, a self-healing PUS based on multiple hydrogen bonding interactions and disulfide bonds was prepared.

Moral sensitivity, moral courage, and ethical behaviour among clinical nurses.

Ethical behaviour in nursing practice is integral to establishing a harmonious nurse-patient relationship and improving the quality of care. A multitude of factors shapes such behaviour. Therefore, it is crucial to understand the interplay between these factors.

Progressive encephalomyelitis with rigidity and myoclonus: a pediatric case report and literature review.

Background: Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and life-threatening autoimmune disease of the central nervous system. So far, only ten cases of PERM have been reported in children worldwide, including the one in this study.

Case Presentation: We report a case of an 11-year-old boy with PERM with an initial presentation of abdominal pain, skin itching, dysuria, urinary retention, truncal and limb rigidity, spasms of the trunk and limbs during sleep, deep and peripheral sensory disturbances, and dysphagia.

The influence of existing piles on station settlement during the construction of a tunnel undercrossing under existing stations.

In the construction of tunnels under existing stations, it is necessary to control their settlement. When there is a pile foundation in the existing station, the pile cutting has a significant impact on the settlement of the existing station. To determine the influence of existing piles on the settlement of subway stations, a reasonable pile-cutting time is proposed.

Insufficient phosphorylation of STAT5 in Tregs inhibits the expression of BLIMP-1 but not IRF4, reduction the proportion of Tregs in pediatric aplastic anemia.

Deficiency in regulatory T cells (Tregs) is an important mechanism underlying the pathogenesis of pediatric aplastic anemia, but its specific mechanism is unclear. In our study, we aimed to investigate whether IL-2/STAT5 can regulate the proliferation of Tregs in aplastic anemia (AA) by regulating their expression of B lymphocyte-induced mature protein-1 (BLIMP-1) or interferon regulatory factor 4 (IRF4). Through clinical research and animal experiments, we found that poor activation of the IL-2/STAT5 signaling pathway may leads to low expression of BLIMP-1 in Tregs of children with AA, which leads to defects in the differentiation and proliferation of Tregs in AA.

Case report of pediatric TTMV-related acute promyelocytic leukemia with central nervous system infiltration and rapid accumulation of RARA-LBD mutations.

is a recently reported fusion gene associated with acute promyelocytic leukemia (APL), caused by the integration of torque teno mini virus (TTMV) genomic fragments into the second intron of the gene. Currently, there have been only six documented cases, with clinical presentations showing significant variability. Although initial responses to all-trans retinoic acid (ATRA) treatment may be observed in patients with ::-APL, the overall prognosis remains unfavorable among infrequent reported cases.

Assessing wound complications in gastroscopy with Streptomyces protease enzyme combined with Shutai.

Current gastroscopy practices necessitate a balance between procedural efficiency and patient safety. It has been hypothesized that increasing procedure outcomes through the use of Streptomyces protease enzyme and Shutai is possible; however, precise nature of any potential adverse reactions and complications remains unknown. In Zhanjiang, China, 213 patients undergoing gastroscopy participated in this controlled trial.

Optimizing Iodine Enrichment through Induced-Fit Transformations in a Flexible Ag(I)-Organic Framework: From Accelerated Adsorption Kinetics to Record-High Storage Density.

Efficient capture and storage of radioactive I is a prerequisite for developing nuclear power but remains a challenge. Here, two flexible Ag-MOFs (FJI-H39 and 40) with similar active sites but different pore sizes and flexibility are prepared; both of them can capture I with excellent removal efficiencies and high adsorption capacities. Due to the more flexible pores, FJI-H39 not only possesses the record-high I storage density among all the reported MOFs but also displays a very fast adsorption kinetic (124 times faster than FJI-H40), while their desorption kinetics are comparable.

Water-stable metal-organic frameworks (MOFs): rational construction and carbon dioxide capture.

Metal-organic frameworks (MOFs) are considered to be a promising porous material due to their excellent porosity and chemical tailorability. However, due to the relatively weak strength of coordination bonds, the stability (, water stability) of MOFs is usually poor, which severely inhibits their practical applications. To prepare water-stable MOFs, several important strategies such as increasing the bonding strength of building units and introducing hydrophobic units have been proposed, and many MOFs with excellent water stability have been prepared.

Renal pelvis sarcomatoid carcinoma with renal vein tumor thrombus: A case report and literature review.

Background: Renal pelvis sarcomatoid carcinoma (RPSC) is a rare and aggressive malignancy whose diagnosis is difficult because radiological imaging results can lead to misclassification as a more common type of renal tumor. In addition, clinical management of patients with RPSC is difficult because of the limited efficacy of available treatments. In this study, we present a comprehensive description of a patient who presented with RPSC and a simultaneous renal vein tumor thrombus.

Age-dependent seasonal growth cessation in .

In temperate and boreal regions, perennial plants adapt their annual growth cycle to the change of seasons. In natural forests, juvenile seedlings usually display longer growth seasons compared to adult trees to ensure their establishment and survival under canopy shade. However, how trees adjust their annual growth according to their age is not known.

The effect of reactive oxygen species (ROS) in immunity and WSSV infection of Scylla paramamosain.

Reactive oxygen species (ROS) are typically regarded as being generated by the cellular respiratory chain or by cells under pathological damage, which play a crucial role as signaling molecules in promoting hemocytes circulation and normal cellular physiological functions. In this study, the antioxidant N-acetylcysteine (NAC) was used to reduce ROS in vivo and in vitro, which to analyze the effect of ROS on innate immunity and viral infection of mud crab. The total hemocyte count (THC), phenoloxidase (PO), superoxide dismutase (SOD) activity, immune-relative genes were analyzed, respectively.

Optimizing Sieving Effect for CO Capture from Humid Air Using an Adaptive Ultramicroporous Framework.

Excessive CO in the air can not only lead to serious climate problems but also cause serious damage to humans in confined spaces. Here, a novel metal-organic framework (FJI-H38) with adaptive ultramicropores and multiple active sites is prepared. It can sieve CO from air with the very high adsorption capacity/selectivity but the lowest adsorption enthalpy among the reported physical adsorbents.

What drives academic peer effects in middle school classrooms in China: Peer composition or peer performance?

This quasi-experimental study estimates academic peer effects in China's middle school (7th-9th grade) classrooms, using data from a large-scale nationally representative survey of middle schoolers in China. Our study design circumvents endogenous sorting by focusing on 52 schools that randomly assigned incoming 7th graders to different 7th-grade classes. Further, reverse causality is addressed by regressing students' 8th-grade test scores on their (randomly assigned) classmates' average 7th-grade test scores.

Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study.

Background: Science, technology, engineering, and mathematics (STEM) professionals are regarded as the highly skilled labor force that fosters economic productivity, enterprise innovation, and international competitiveness of a country. This study aims to understand the genetic predisposition to STEM occupations and investigate its associations with regional economic performance. We conducted a genome-wide association study on the occupational choice of STEM jobs based on a sample of 178,976 participants from the UK Biobank database.

Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.

Background: Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanism of Sp1 in tumour progression remain unclear.

The impact of echinococcosis interventions on economic outcomes in Qinghai Province of China: Evidence from county-level panel data.

Introduction: Echinococcosis can incur substantial economic losses for the livestock industry by causing organ condemnation, delayed growth, and reduced meat and wool output and quality in sheep and cattle, as well as increased surgery costs, hospital care, and decreased productivity in humans. Yet echinococcosis could be prevented and controlled by interventions, such as dog management and deworming, lamb vaccination, slaughter management, and training and public education.

Methods: Exploiting temporal and spatial variations in the number of intervention measures implemented in 39 counties in Qinghai province of China in 2015-2020, this study assesses the economic impact of echinococcosis interventions using a dynamic difference-in-differences model.

Application of EEG in migraine.

Migraine is a common disease of the nervous system that seriously affects the quality of life of patients and constitutes a growing global health crisis. However, many limitations and challenges exist in migraine research, including the unclear etiology and the lack of specific biomarkers for diagnosis and treatment. Electroencephalography (EEG) is a neurophysiological technique for measuring brain activity.