Nonlinear acceleration disturbance observer to reject transient peak disturbances for an inertial stabilization-tracking platform.

A high-bandwidth nonlinear acceleration disturbance observer (NOADOB) is proposed to reject transient peak disturbances mainly arising from velocity commutation of an inertial stabilization-tracking platform (ISTP). The approach is essentially based on extracting acceleration peak signals and applying a saturation function. The observer structure employs acceleration measurements and combines velocity loop input and control quantity to acquire peak signals.

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens.

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing studies show that the JAK/STAT pathway regulates the downstream signaling of numerous membrane proteins such as such as G-protein-associated receptors, integrins and so on. Mounting evidence shows that the JAK/STAT pathways play an important role in human disease pathology and pharmacological mechanism.