Genome-Wide Identification and Expression Profiling Analysis of the CCT Gene Family in and .

CCT family genes play crucial roles in photoperiodic flowering and environmental stress response; however, there are limited reports in species with considerable edible and medicinal value. In this study, we conducted genome-wide characterization and expression profiling analysis of the CCT gene family in two species: tomato ( L.) and eggplant ( L.

Mechanisms and control measures of low temperature storage-induced chilling injury to solanaceous vegetables and fruits.

Low temperature storage is widely used for storage and transportation of fruits and vegetables after harvest. As a cold-sensitive fruit vegetable, post-harvest solanaceous vegetables and fruits are susceptible to chilling injury during low temperature storage, which reduces its sensory quality and edible quality and shortens its storage period, thus leading to huge economic losses. Therefore, it is an essential to clarify the occurrence mechanism of chilling injury caused by low temperature storage in solanaceous vegetables and fruits, and to propose corresponding prevention and control measures for chilling injury.

Comparative Analysis of the Mitochondrial Genome of Eggplant ( L.) to Identify Cytoplasmic Male Sterility Candidate Genes.

Cytoplasmic male sterility (CMS) is important for commercial hybrid seed production. However, it is still not used in eggplant ( L.), and corresponding regulatory genes and mechanisms of action have not been reported.

Moving sampling physics-informed neural networks induced by moving mesh PDE.

In this work, we propose an end-to-end adaptive sampling framework based on deep neural networks and the moving mesh method (MMPDE-Net), which can adaptively generate new sampling points by solving the moving mesh PDE. This model focuses on improving the quality of sampling points generation. Moreover, we develop an iterative algorithm based on MMPDE-Net, which makes sampling points distribute more precisely and controllably.

Identification and Analysis of WRKY Transcription Factors in Response to Cowpea Fusarium Wilt in Cowpea.

In plants, WRKY transcription factors play a crucial role in plant growth, development, and response to abiotic and biotic stress. Cowpea () is an important legume crop. However, cowpea Fusarium wilt (CFW), caused by (Fot), poses a serious threat to its production.

Tomato SlWRKY3 Negatively Regulates Resistance via .

is considered the second most important fungal plant pathogen, and can cause serious disease, especially on tomato. The gene encodes a receptor-like kinase that can positively regulate plant resistance to . Here, we identified a tomato WRKY transcription factor SlWRKY3 that binds to the W-box on the promoter.

BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.

Background: Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date.

Cr(VI) Reduction and Sequestration by FeS Nanoparticles Formed in situ as Aquifer Material Coating to Create a Regenerable Reactive Zone.

Remediation of large and dilute plumes of groundwater contaminated by oxidized pollutants such as chromate is a common and difficult challenge. Herein, we show that in situ formation of FeS nanoparticles (using dissolved Fe(II), S(-II), and natural organic matter as a nucleating template) results in uniform coating of aquifer material to create a regenerable reactive zone that mitigates Cr(VI) migration. Flow-through columns packed with quartz sand are amended first with an Fe solution and then with a HS solution to form a nano-FeS coating on the sand, which does not hinder permeability.

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin.

The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed, which limits the anti-tumor efficiency of inhibitors targeting the upstream of Wnt/β-catenin pathway. The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant Stephania cepharantha Hayata has been reported in various types of tumors. We previously observed that its derivatives inhibited the Wnt/β-catenin signaling in liver cancer; however, the specific mechanism remains unknown.

Salt Tolerance in : Elucidating Growth and Physiological Adaptations to Saline Environments.

Adversity stress is the main environmental factor limiting plant growth and development, including salt and other stress factors. This study delves into the adaptability and salt tolerance mechanisms of , a species with potential for cultivation in salinized areas. We subjected the plants to various salt concentrations to observe their growth responses and to assess key physiological and biochemical indicators.

Genome-wide transcriptome profiling reveals molecular response pathways of in response to salt stress.

exhibits a strong biological control effect on many important plant pathogens, such as , , and . However, its biocontrol effectiveness is weakened or reduced under salt stress. The aim of this study was to investigate the molecular response of to salt stress at the whole-genome level.

The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis.

Acute liver failure caused by alcoholic hepatitis (AH) is only effectively treated with liver transplantation. Livers of patients with AH show a unique molecular signature characterized by defective hepatocellular redox metabolism, concurrent to hepatic infiltration of neutrophils that express myeloperoxidase (MPO) and form neutrophil extracellular traps (NETs). Exacerbated NET formation and MPO activity contribute to liver damage in mice with AH and predicts poor prognosis in AH patients.

Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.

Wnt/β-catenin signaling pathway is a classical and crucial oncogenic pathway in many carcinomas, and Porcupine (PORCN) is an O-acyltransferase, which is indispensable and highly specific for catalyzing palmitoylation of Wnt ligands and facilitating their secretion and biofunction. Targeting PORCN provides a promising approach to specifically cure Wnt-driven cancers from the root. In this study, we designed series of pyridonyl acetamide compounds, and discovered a novel PORCN inhibitor WHN-88 with a unique di-iodinated pyridone structural fragment, which is significantly different from the reported inhibitors.

The Genome of f. sp. Provides Insight into the Evolution of Genomes and Effectors of Species.

f. sp. , the causal agent of cowpea fusarium wilt, is a serious threat to cowpea production in China.

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis.

Background And Aims: Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (AH) are unknown. We aimed to identify subpopulations of collagen type 1 alpha 1 (Col1a1)-expressing cells in a mouse AH model by single-cell RNA sequencing (scRNA-seq) and filtering the cells with the HSC (lecithin retinol acyltransferase [Lrat]) and portal fibroblast (Thy-1 cell surface antigen [Thy1] and fibulin 2 [Fbln2]) markers and vitamin A (VitA) storage.

Approach And Results: Col1a1-green fluorescent protein (GFP) mice underwent AH, CCl 4 , and bile duct ligation (BDL) procedures to have comparable F1-F2 liver fibrosis.

Node, place, ridership, and time model for rail-transit stations: a case study.

Nowadays, Transit-Oriented Development (TOD) plays a vital role for public transport planners in developing potential city facilities. Knowing the necessity of this concept indicates that TOD effective parameters such as network accessibility (node value) and station-area land use (place value) should be considered in city development projects. To manage the coordination between these two factors, we need to consider ridership and peak and off-peak hours as essential enablers in our investigations.

A novel regulatory complex mediated by Lanata (Ln) controls multicellular trichome formation in tomato.

Trichomes that originate from plant aerial epidermis act as mechanical and chemical barriers against herbivores. Although several regulators have recently been identified, the regulatory pathway underlying multicellular trichome formation remains largely unknown in tomato. Here, we report a novel HD-ZIP IV transcription factor, Lanata (Ln), a missense mutation which caused the hairy phenotype.

Structural Performance of EB-FRP-Strengthened RC T-Beams Subjected to Combined Torsion and Shear Using ANN.

This research study applied Artificial Neural Networks (ANNs) to predict and evaluate the structural responses of externally bonded FRP (EB-FRP)-strengthened RC T-beams under combined torsion and shear. Previous studies proved that, compared to reinforced concrete (RC) rectangular beams, RC T-beams performance in shear is significantly higher in structural analysis and design. The structural response of RC beams experiences a critical change while torsion moments are applied in load conditions.

Structural Behavior of FRP-Retrofitted RC Beams under Combined Torsion and Bending.

Fiber-reinforced polymers (FRPs) retrofit reinforced concrete (RC) structures. ABAQUS finite element software was used to perform numerical parametric analysis on a group of RC beams in this research. All specimens were retrofitted by FRP strips as an external retrofitting and experimentally tested up to previous researchers' failure points.

Application of artificial neural networks and multiple linear regression on local bond stress equation of UHPC and reinforcing steel bars.

We investigated the use of an Artificial Neural Network (ANN) to predict the Local Bond Stress (LBS) between Ultra-High-Performance Concrete (UHPC) and steel bars, in order to evaluate the accuracy of our LBS equation, proposed by Multiple Linear Regression (MLR). The experimental and numerical LBS results of specimens, based on RILEM standards and using pullout tests, were assessed by the ANN algorithm using the TensorFlow platform. For each specimen, steel bar diameters ([Formula: see text] of 12, 14, 16, 18, and 20, concrete compressive strength ([Formula: see text]), bond lengths ([Formula: see text]), and concrete covers ([Formula: see text]) of [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] were used as input parameters for our ANN.