Publications by authors named "Qigui Xu"
Impressive clinical benefit is seen in clinic with PD-1 inhibitors on portion of cancer patients. Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. Tumor-associated macrophage (TAM), a type of M2-polarized macrophage, eliminates or suppresses T-cell-mediated anti-tumor responses.
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- A new method using organocatalysts for a specific chemical reaction involving ortho-hydroxyphenyl-substituted p-QMs and α-nitroketones has been developed.
- The process results in the creation of unique chiral compounds, specifically 2-(1-(4-hydroxyphenyl)ethyl)phenols, with impressive yields and enantioselectivities.
- The technique is efficient enough to be scaled up for larger experiments, demonstrating its practical application.