Publications by authors named "Qigao Yan"

The purpose of this experiment is to understand how miR-1285-3P regulates the NOTCH signaling pathway by targeting, thereby affecting the proliferation and differentiation of hair follicle stem cells. The cultured Inner Mongolia hair follicle stem cells were used in this experiment, and they were divided into control group, blank transfection group and miR-1285-3P transfection group. Among them, the control group was left untreated; the blank group was given miR-NC transfection; at the same time, the miR-1285-3P transfection group was given miR-1285-3P mimics for transfection.

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Objective: To investigate the enhancement of chemosensitivity of tamoxifen (TAM) in triple negative breast cancer (TNBC) by celastrol (CEL) through mitochondrial mediated pathway.

Methods: Human TNBC MDA-MB-231 cells were divided to the control group (medium treatment), TAM-L group (low concentration TAM treatment, 0.5 μM TAM treatment), TAM-H group (1 μM TAM treatment), CEL-L group (low concentration CEL treatment, 1 μM CEL), CEL-H group (high concentration CEL treatment, 3 μM CEL), CEL-L+TAM group (low concentration CEL and TAM co-treatment) and CEL-H+TAM group (high concentration of CEL co-treated with TAM).

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