Publications by authors named "Qifei He"
Article Synopsis
- Inflammation and ECM degradation are critical factors in the development of osteoarthritis (OA), and the study explores the protective role of Wedelolactone, a natural compound derived from medicinal plants.
- Pretreatment with Wedelolactone suppresses key inflammatory markers (like COX-2 and TNF-α) and enhances ECM-related proteins (like Collagen II) in chondrocytes, indicating its potential to protect against OA.
- The study reveals that Wedelolactone inhibits the NF-κB signaling pathway, which is central to inflammation in OA, and shows promise in relieving cartilage damage in animal models, suggesting its therapeutic potential for OA treatment.
Despite recent advances, rheumatoid arthritis (RA) patients remain refractory to therapy. Dysregulated overproduction of angiopoietin-like protein 4 (ANGPTL4) is thought to contribute to the disease development. ANGPTL4 was initially identified as a regulator of lipid metabolism, which is hydrolyzed to N-terminal and C-terminal (cANGPTL4) fragments in vivo.
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- HER2(+) gastric cancer patients can potentially benefit from the addition of trastuzumab in treatment, but its effects on immune cells were previously unclear.
- A study analyzing immune cell profiles in over 1,300 patients found significant differences in T cell infiltration between HER2(+) and HER2(-) gastric cancer, with trastuzumab improving immune responses in treated patients.
- The findings suggest that trastuzumab not only influences cancer treatment outcomes but may also enhance the immune environment, supporting further exploration of combined immunotherapy strategies for these patients.
Background: Neutrophil/lymphocyte ratio (NLR) is a vital index for systemic inflammation and a prognostic indicator for gastric cancer (GC). Despite the abundant literature on NLR's prognostic value for GC, the underlying factors mediating its impact on survival remain unclear. The objective of this study was to analyze the role of NLR in different prognostic models and subgroups, and investigate the mediating effects of immune infiltrates between NLR and survival.
View Article and Find Full Text PDFBackground: Calf muscle venous thrombosis (CMVT) is among the most important medical complications after hip surgery. CMVT has been known for many years, but many opinions about the incidence and risk factors of CMVT are still controversial. The objective of this retrospective study was to investigate the incidence and associated risk factors of postoperative CMVT in patients with hip fractures.
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- Osteoarthritis (OA) is a common degenerative joint disease where inflammation is crucial for its development; CAPE, a natural flavonoid, shows promise in reducing this inflammation.
- In studies with IL-1β-stimulated chondrocytes and rat models, CAPE decreased harmful enzymes and inflammatory markers, while promoting substances that help maintain cartilage structure.
- The findings suggest that CAPE could be a potential treatment or preventative measure for OA, as it effectively protects cartilage and slows disease progression.
Rapid proliferation and metastasis of gastric cancer (GC) resulted in a poor prognosis in the clinic. Previous studies elucidated that long non-coding RNA (LncRNA) LINC00205 was upregulated in various tumors and participated in tumor progression. The aim of our study was to investigate the regulating role of LINC00205 in tumorigenesis and metastasis of GC.
View Article and Find Full Text PDFThere is a continued need for investigating the roles of microRNAs (miRNAs) and their targets on the progression of gastric cancer (GC), especially metastasis. Here, we performed an integrated study to identify dysregulated miRNAs critical for GC development and progression. miR-135b was determined as a promising biomarker for GC.
View Article and Find Full Text PDFBackground: Recent studies have reported a beneficial role of trastuzumab in neoadjuvant treatment (NAT) among resectable gastric cancer (GC) patients; however, the effect of adjuvant treatment (AT) combined with trastuzumab is understudied. We performed a retrospective cohort study to compare chemotherapies with or without trastuzumab among human epidermal growth factor receptor 2-positive (HER2 +) locally advanced GC patients in the AT and NAT settings, respectively.
Methods: We enrolled 208 HER2 + resected GC patients who underwent perioperative/postoperative treatment in 2010-2019 in a single-centered hospital, including 135 AT patients and 73 NAT patients.
Background: Positive peritoneal cytology (PCY) indicates metastasis (M1) in gastric cancer (GC) patients; both the American and Chinese guidelines recommend laparoscopic peritoneal lavage (LPL) for cytology. However, relatively high costs impair the widespread use of LPL in some resource-limited regions in China, and the cost-effectiveness of PCY testing remains unclear. Therefore, we performed a decision analysis to evaluate the cost-effectiveness of PCY testing by comparing the guideline-recommended intraoperative LPL, a newly proposed preoperative percutaneous peritoneal lavage (PPL), and a third strategy of exploratory laparotomy with no cytology testing (ELNC) among GC patients.
View Article and Find Full Text PDFBackground: To investigate whether there is a distinct difference in prognosis between hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) and whether HAS can benefit from radical surgery.
Methods: We retrospectively reviewed 722 patients with non-HAS and 75 patients with HAS who underwent radical gastrectomy between 3 November 2009 and 17 December 2018. Propensity score matching (PSM) analysis was used to eliminate the bias among the patients in our study.
Transportation is an important link in the mining process, and large trucks are one of the important tools for mine transportation. Due to their large size and small driving position, large trucks have a blind spot, which is a hidden danger to the safe transportation of mines and has a great impact on production efficiency and economic loss. The traditional large truck safety warning system mainly uses the ultrasonic short-distance ranging method, radar ranging method, GPS (Global Positioning System) technology, and so on.
View Article and Find Full Text PDFBackground: In treatment of ankle fracture, intraoperative stress tests are used to assess the syndesmotic injury and instability. However, the optimized timing of the strees test should be applied whether in pre- or post-bony fixation during operation is seldom be reported in previous studies. The different strategies on stress test timing would exhibit opposite results within a type of pronation-external rotation (PER) fractures with supracollicular medial malleolar (SMM) fractures.
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