Publications by authors named "Qichuan Jin"
Article Synopsis
- Essential thrombocythemia (ET) with double driver mutations, such as MPL and CALR, is rare, and this study presents a unique case of a patient with both MPL S204P and Type 2 CALR mutations.
- The patient's ET progressed to an accelerated phase just 3.5 months after diagnosis, during which the CALR mutation disappeared and new mutations, including ASXL1 and ETV6, emerged.
- This case emphasizes the importance of using next-generation sequencing (NGS) to screen for additional mutations in ET patients, as it can provide crucial insights into prognosis, especially during disease progression.
Carcinogenesis
October 2021
Article Synopsis
- Bortezomib-based chemotherapy is commonly used for multiple myeloma (MM), but drug resistance remains a significant challenge.
- Myeloma cells produce high levels of dickkopf-1 (DKK1), which is linked to bone disease and resistance to bortezomib, with the study revealing that DKK1 downregulates WWP2, an important protein involved in drug response.
- The research indicates that targeting the DKK1-WWP2-GLI2 pathway may improve sensitivity of myeloma cells to bortezomib, presenting a potential strategy for enhancing treatment efficacy.
