Triple-Combination Therapy with a Multifunctional Yolk-Shell Nanozyme Au@CeO Loaded with Dimethyl Fumarate for Periodontitis.

Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and is one of the most prevalent and complex oral conditions. Oxidative stress induced by the excessive generation of reactive oxygen species (ROS) leads to periodontitis, which is closely associated with pathological processes, including mitochondrial dysfunction of periodontal cells and local immune dysregulation. However, current treatment modalities that target single pathological processes have limited long-term therapeutic effects.

Cyanogel-Induced Facile Synthesis of Palladium Hydride for Electrocatalytic Oxygen Reduction.

Palladium hydride (PdH) is one of the well-known electrocatalytic materials, yet its synthesis is still a challenge through an energy-efficient and straightforward method. Herein, we propose a new and facile cyanogel-assisted synthesis strategy for the preparation of PdH at a mild environment with NaBH as the hydrogen source. Unlike traditional inorganic Pd precursors, the unique Pd-CN-Pd bridge in Pd[Pd(CN)] ⋅ aHO cyanogel offers more favourable spatial sites for insertion of H atoms.

Research on the synergistic modification effect and the interface mechanism of GO/SBS compound-modified asphalt based on experiments and molecular simulations.

Although there have been reports showing the modification effect of carbon nanomaterials on asphalt, there are few studies on whether carbon nanomaterials and polymers can have synergistic modification effects on asphalt. At the same time, the complex composition of asphalt makes it difficult to determine the interface mechanism between the modifier and the asphalt. In this study, graphene oxide (GO) and styrene-butadiene-styrene block copolymer (SBS) were selected as modifiers.

Competitive Adsorption: Reducing the Poisoning Effect of Adsorbed Hydroxyl on Ru Single-Atom Site with SnO for Efficient Hydrogen Evolution.

Ruthenium (Ru) has been theoretically considered a viable alkaline hydrogen evolution reaction electrocatalyst due to its fast water dissociation kinetics. However, its strong affinity to the adsorbed hydroxyl (OH ) blocks the active sites, resulting in unsatisfactory performance during the practical HER process. Here, we first reported a competitive adsorption strategy for the construction of SnO nanoparticles doped with Ru single-atoms supported on carbon (Ru SAs-SnO /C) via atomic galvanic replacement.

Evaluation of the Composite Mechanism of Nano-FeO/Asphalt Based on Molecular Simulation and Experiments.

Asphalt, as an indispensable binder in road paving, plays an important role in transportation development. However, the mechanism of action between the modifier and asphalt cannot be fully explained by the existing test methods. This paper combines molecular simulations with experiments to provide a research and analysis tool to evaluate the "structure-performance" relationship of asphalt.

Computational and Experimental Insights into the Role of Acidic Molecules on the Corrosion Behavior on 7A46 Aluminum Alloy.

The corrosion mechanisms for different corrosive media on the aged 7A46 aluminum alloy were systematically investigated at nanoscale level. The combination of empirical intergranular and exfoliation corrosion behavior was employed, and coupled with first-principles calculations. Results revealed that the dispersed distribution of matrix precipitates (MPs) leads to the enhancement of the corrosion resistance pre-ageing (PA) followed by double-ageing (PA-DA) alloy.

Research on the Mechanism of Interaction between Styrene-Butadiene-Styrene (SBS) and Asphalt Based on Molecular Vibration Frequency.

Based on the four-component theory of asphalt, molecular models of the saturate, aromatic, resin, and asphaltene were constructed, respectively. The styrene-butadiene-styrene (SBS) polymer was used as the modifier. Using density functional theory (DFT) to study the effect of SBS on the molecular vibration of each component of asphalt, the vibration spectrums and binding energy of the systems composed of SBS and each component molecule of asphalt were calculated.

Rolling membrane powered by low-temperature steam as a new approach to generate mechanical energy.

How to convert heat energy into other forms of usable energy more efficiently is always crucial for our human society. In traditional heat engines, such as the steam engine and the internal combustion engine, high-grade heat energy can be easily converted into mechanical energy, while a large amount of low-grade heat energy is usually wasted owing to its disadvantage in the temperature level. In this work, for the first time, the generation of mechanical energy from both high- and low-temperature steam is implemented by a hydrophilic polymer membrane.

Cathepsin C promotes the progression of periapical periodontitis.

Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed; this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing.

Multi-Walled Carbon Nanotubes Enhanced the Performance of Epoxy Asphalt Pavement Binder.

Modifying epoxy asphalt with nanomaterials is an effective method to enhance the performance of epoxy asphalt binder. The carbon nanotubes were modified and carbon nanotubes/epoxy asphalt (CNTs-EA) was fabricated by mechanical stirring. The performanceof CNTs-EA pavement binder (CNTs-EAPB) was analyzed by immersion marshall's, freeze-thaw splitting and dynamic stability tests.

A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.

Refractory periapical periodontitis, which is a persistent infection after root canal treatment, still has no effective treatment. Its most common pathogen is Enterococcus faecalis. Here, the precursor of phytosteroids, dioscin, is introduced to fight against the inflammation induced by Enterococcus faecalis.

Free volume, gas permeation, and proton conductivity in MIL-101-SOH/Nafion composite membranes.

A series of MIL-101-SO3H/Nafion composite membranes was synthesized. They show an improved proton conductivity, due to the abundance of SO3H groups, which fosters proton conduction by binding the water molecules and enabling a larger number of conducting sites. Gas (including water vapor, hydrogen, and oxygen) permeability, crystallinity, and free volumes of the MIL-101-SO3H/Nafion composite membranes were investigated, as well as their correlation.