Safety, pharmacokinetics, and food effect of sudapyridine (WX-081), a novel anti-tuberculosis candidate in healthy Chinese subjects.

This study aimed to assess the safety, pharmacokinetics, and food impact on sudapyridine (WX-081), a novel drug designed to inhibit mycobacterium ATP synthase, with clinical applications for drug-resistant tuberculosis (TB) treatment. The research comprised two arms: a single ascending dose (SAD) arm (30 to 600 mg, N = 52) and a multiple ascending dose (MAD) arm (200 to 400 mg, N = 30). The influence of food was evaluated using a 400 mg dose within an SAD cohort.

Kinematics and geometric features of the s-cone test piece: identifying the performance of five-axis machine tools using a new test piece.

The design of machine parts of different sizes and shapes has become relevant in the manufacturing industry which requires five-axis machine tools of high dynamic performance; different machining test pieces have been used to test and reflect the machine tool's performance. The S-shaped is still under development and consideration of which a new test piece better than the S-shaped part has been recommended to be put forward making the NAS979 the only standardized test piece; however, it has some limitations. Hence, this study proposes a new test piece to objectively satisfy the demand for machine tools with higher dynamic performance, which shows much improvement over the standard NAS979 and is the best alternative to the S-shaped test piece, and it combines the geometric and kinematic features of both test pieces.

Adaptive changes of foot pressure in hallux valgus patients.

Background: Hallux valgus (HV) is one of the most common deformities in podiatric and orthopedic practice. Plantar pressure technology has been widely used in studying the pressure distribution in HV patients for better assessment to plan interventions. However, previous studies produced an array of controversial findings and most of them only focused on the forefoot.