OTUD7B is a new deubiquitinase targeting p53.

The tumor suppressor p53 safeguards against cellular transformation, with its expression regulated by diverse post-translational modifications (PTMs). While polyubiquitination by Mdm2 principally drives its proteasomal degradation, the identity of p53 deubiquitinases (DUBs) remains less well defined. This study investigates the role of the deubiquitinase enzyme OTUD7B in hepatocellular carcinoma (HCC), where it is notably downregulated and proposed to function as a tumor suppressor.

Soft and lightweight fabric enables powerful and high-range pneumatic actuation.

Soft structures and actuation allow robots, conventionally consisting of rigid components, to perform more compliant, adaptive interactions similar to living creatures. Although numerous functions of these types of actuators have been demonstrated in the literature, their hyperelastic designs generally suffer from limited workspaces and load-carrying capabilities primarily due to their structural stretchability factor. Here, we describe a series of pneumatic actuators based on soft but less stretchable fabric that can simultaneously perform tunable workspace and bear a high payload.