Publications by authors named "Qiaozhuan Li"
Article Synopsis
- The study investigates how inhibiting the PARG protein affects the metastatic behavior of colon cancer cells.
- By using RNA interference and mouse models, researchers found that knocking down PARG decreased the ability of these cancer cells to invade and migrate, while also affecting related genes.
- Results showed that while PARG knockdown led to higher Akt phosphorylation and lower levels of NF-κB, the inhibition of the Akt pathway did not lead to further changes, indicating that PARG impacts metastasis primarily through the PI3K/Akt signaling pathway.
- Overall, the conclusion suggests that targeting PARG may be a potential strategy for reducing metastasis in colon carcinoma.
Poly ADP-ribose polymerase (PARP) which is closely related to Poly ADP-ribose glycohydrolase (PARG) has already been thoroughly investigated in both experimental and clinical cancer trials compared to the latter. Nevertheless, in this experiment the importance of PARG expression was highlighted; whereby it is being silenced via lentivirus vector-mediated short hairpin RNA (shRNA). MTT assay showed that there was an inhibition in human Lovo colon cancer cell growth and flow cytometry demonstrated an increase in the population of cells in G(0)/G(1) phase with a decrease in the S phase in transfected Lovo cells.
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