Diagnostic value and clinical significance of lncRNA combined with miR-425-3p in children with viral myocarditis.

Background: Viral myocarditis (VMC) is common in children. Previous studies have reported the clinical value of nuclear paraspeckle assembly transcript 1 (NEAT1) and microRNA-425-3p (miR-425-3p) in certain diseases, but not in VMC. This article was designed to investigate the expression of long noncoding RNA (lncRNA) NEAT1 and miR-425-3p in the serum of patients with VMC and their clinical significance.

Strategy to synthesize dual-emission carbon dots and their application for pH variation and hydrogen sulfide sensing and bioimaging.

In this work, dual emission nitrogen and sulfur co-doped fluorescent carbon dots (DE-CDs) were designed for pH variation and hydrogen sulfide (HS) sensing and bioimaging through fluorescence enhancement. The DE-CDs with green-orange emission were facilely prepared by one-pot hydrothermal strategy using neutral red and sodium 1,4-dinitrobenzene sulfonate as precursors, manifesting intriguing dual-emission behavior at 502 and 562 nm. As the pH increases from 2.

Strategy to synthesize long-wavelength emission carbon dots and their multifunctional application for pH variation and arginine sensing and bioimaging.

In this work, we designed N and S co-doped carbon dots (N,S-CDs) with long-wavelength emission and their multifunctional application in pH variation, arginine (Arg) sensing, bioimaging in living cells and zebrafish, and fluorescent materials. The N,S-CDs with excitation wavelength-dependent properties were prepared using neutral red (NR) and dl-methionine (DL-Met) as raw materials by one-pot hydrothermal strategy. The N,S-CDs exhibited a unique pH-sensitive luminescence trait within pH range of 3.

Characteristics of Nosocomial Infections in Children Screened for SARS-CoV-2 Infection in China.

BACKGROUND This study summarizes the characteristics of children screened for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and reports the case of 1 child who was diagnosed with SARS-CoV-2 infection in Guangzhou Women and Children's Medical Center and the cases of his family members. MATERIAL AND METHODS The medical records of 159 children who were admitted to our hospital from January 23 to March 20, 2020, were retrospectively analyzed. Samples from pharyngeal or/and anal swabs were subjected to reverse-transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 within 12 h of patient admission; a second RT-PCR test was done 24 h after the first test.

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.

We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases.

Wnt/Beta-Catenin Signaling and Prostate Cancer Therapy Resistance.

Metastatic or locally advanced prostate cancer (PCa) is typically treated with androgen deprivation therapy (ADT). Initially, PCa responds to the treatment and regresses. However, PCa almost always develops resistance to androgen deprivation and progresses to castrate-resistant prostate cancer (CRPCa), a currently incurable form of PCa.

The Role of Maternal HP1a in Early Embryogenesis via Regulation of Maternal Transcript Production.

Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early embryogenesis.

The effects of meteorological factors on influenza among children in Guangzhou, China.

Background: Influenza seriously affects the health of children, yet little evidence is available on the association between meteorological factors and the occurrence of influenza among children in subtropical regions. The current study aimed to explore the effects of meteorological factors on influenza among children in Guangzhou, a subtropical city in China.

Methods: The distributed lag nonlinear model (DLNM) was used to assess the effects of meteorological factors on children influenza occurrence in Guangzhou, China.

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells.

Pancreatic ductal adenocarcinoma (PDAC) is a dynamic tumor supported by several stromal elements such as pancreatic stellate cells (PSC). Significant crosstalk exists between PSCs and tumor cells to stimulate oncogenic signaling and malignant progression of PDAC. However, how PSCs activate intercellular signaling in PDAC cells remains to be elucidated.

Relationships between weight status and bullying victimization among school-aged adolescents in Guangdong Province of China.

Objective: To examine relationships between weight status and different forms of bullying victimization among adolescents aged 11-18 years.

Methods: The relationships between weight status and bullying victimization (physical, verbal, and relational) were examined utilizing data from the Guangdong Provincial Youth Health Behavior Survey. Data on height, weight, and victimization behaviors were collected by self-reporting from 12 439 subjects.

[Evaluation on the health education program regarding prevention of non-fatal drowning among school-aged children in Lianping county, Guangdong province].

Objective: To evaluate the outcome of health education program on drowning prevention among primary and secondary school children in rural areas.

Methods: A township was selected and all the students from grade 3 to 5, grade 7 to 8, and grade 10 to 11 were selected to take part in the program. Twelve intervention measures on natural water safety and drowning prevention were carried out for one year.