Asymmetric Total Synthesis of (+)-Mannolide C.

(+)-Mannolide C is a complex hexacyclic C cephalotane-type diterpenoid featuring a highly strained 7/6/6/5 tetracyclic core containing eight consecutive stereocenters and two bridging lactones. The first asymmetric total synthesis of (+)-mannolide C has been accomplished by lipase-mediated resolution, Ru-complex-catalyzed double ring-closing metathesis (RCM) reactions, Ni -catalyzed diastereoselective Michael addition, and Mn -catalyzed allylic oxidation as the key transformations.

Correction: Decarboxylative C-C coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols.

Correction for 'Decarboxylative C-C coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols' by Sasa Wang et al., Chem. Commun.

Decarboxylative Csp(3)-Csp(3) coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols.

A new decarboxylative Csp(3)-Csp(3) coupling approach for the benzylation of ketone enolates has been developed. A variety of raspberry ketone derivatives were conveniently synthesized in good to excellent yields under mild conditions. A crossover reaction shed light on the mechanism of this tandem reaction.