Enantioselective Reduction and Sulfenylation of Isoflavanone Derivatives via Bisguanidinium Hypervalent Silicate.

In this work, we describe an enantioselective reduction and sulfenylation of isoflavanone derivatives by an ion pair strategy. The chiral cationic catalyst bisguanidinium () is capable of chiral induction in catalytic systems. Silane hydride works as a reductant and helps to form an anionic hypervalent silicate complex and intermediates with substrates to pair with chiral catalyst.

Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors in .

Six series of benzoheterocyclic sulfoxide derivatives were designed and synthesised as () quorum sensing inhibitors in this paper. We experimentally demonstrated that significantly inhibited the formation of PAO1 biofilm without affecting the growth. Further mechanistic studies showed that affected the luminescence of quorum sensing reported strain PAO1-- and the production of PAO1 elastase virulence factor which was regulated by system.

The Molecular Architecture of Quorum-Sensing Inhibitors.

The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the goals of survival and reproduction. Quorum sensing (QS) is an intercellular communication system based on cell density that can regulate bacterial virulence and biofilm formation.