SIVA-1 enhances acquired chemotherapeutic drug resistance of gastric cancer in vivo by regulating the ARF/MDM2/p53 pathway.

SIVA-1 has been shown to affect apoptotic processes in various different cell lines, and SIVA-1 significantly contributes to the decreased responsiveness of cancer cells to some chemotherapy agents. However, whether SIVA-1 has potential application in gastric cancer remains unknown. Therefore, the objective of this investigation was to clarify the distinct function of SIVA-1 in chemotherapeutic drug resistance within a living murine model with gastric malignancy, and initially elucidate the underlying mechanisms.

Optimizing classroom modularity and combinations to enhance daylighting performance and outdoor platform through ANN acceleration in the post-epidemic era.

The global COVID-19 pandemic has increased attention to the relationship between the built environment and health, particularly in educational settings where students spend a significant amount of their time. Traditional side daylighting used in schools, while cost-effective and easy to construct, can result in uneven indoor daylighting. To address this issue, this paper proposes a terraced teaching building design model for primary and secondary schools in Guangzhou based on the design experience of an "open-air school movement" during a historical respiratory epidemic in the early 20th century.

Physical Connectivity as Enabler of Unexpected Encounters With Information in Campus Development: A Case Study of South China University of Technology.

This paper is an attempt to advance research on spatial potential for interdisciplinary innovation of university campuses by proposing a spatial quantitative method. The aim is to develop the campus to adapt to the new pedagogical structure of encouraging interdisciplinary innovation in the era of knowledge society. For this purpose, literature from management, psychology, and architecture are reviewed to provide insight into the relationship between innovation and physical environment.

Propensity score-matched comparison between totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction and conventional laparoscopic surgery with mini-laparotomy in the treatment of ascending colon cancer (with video).

Background And Aims: Now that the debate about the safety and effectiveness of laparoscopic versus open surgery is over, attention has turned to innovations that can verify whether minimizing the impact of laparoscopy on the abdominal wall can further reduce pain, improve patient comfort, lead to superior cosmesis, and reduce morbidity. The aim of this study was to further explore the application value of totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction (NOSE) and to evaluate the short-term efficacy of transcolonic NOSE surgery for resecting specimens of ascending colon cancer.

Methods: From January 2016 to May 2017, a retrospective study was conducted in Guangxi.

Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway.

Siva‑1 is a well‑known anti‑apoptosis protein that serves a role in multiple types of cancer cells. However, whether Siva‑1 affects multidrug resistance via the NF‑κB pathway in gastric cancer is currently unknown. The present study aimed to determine the possible involvement of Siva‑1 in gastric cancer anticancer drug resistance in vitro.

Pilot study of a novel classroom designed to prevent myopia by increasing children's exposure to outdoor light.

We sought to assess light characteristics and user acceptability of a prototype Bright Classroom (BC), designed to prevent children's myopia by exposing them to light conditions resembling the outdoors. Conditions were measured throughout the school year in the glass-constructed BC, a traditional classroom (TC) and outdoors. Teachers and children completed user questionnaires, and children rated reading comfort at different light intensities.