Publications by authors named "Qiaolin Du"
Article Synopsis
- Guided bone regeneration (GBR) uses barrier membranes to repair bone defects, but current membranes face challenges like poor mechanical strength and inadequate degradation rates.
- New composite membranes made of amorphous calcium phosphate-carboxylated chitosan-polyvinyl alcohol (ACP-CCS-PVA) show improved mechanical and osteogenic properties, thanks to the incorporation of ACP nanoparticles.
- However, while ACP enhances performance, too much of it can hinder cell growth and bone formation, emphasizing the need for a balance in biomaterial composition.
Biomineralization of collagen fibers is regulated by non-collagenous proteins and small biomolecules, which are essential in bone and teeth formation. In particular, small biomolecules such as succinic acid (SA) exist at a high level in hard tissues, but their role is yet unclear. Here, our work demonstrated that SA could significantly promote intrafibrillar mineralization in two- and three-dimensional collagen models, where the relative mineralization rate was 16 times faster than the control group.
View Article and Find Full Text PDFIt is currently known that crosslinking agents can effectively improve the mechanical properties of dentin by crosslinking type I collagen. However, few scholars have focused on the influence of crosslinking agents on the collagen-mineral interface after crosslinking. Analysis of the Fourier transform infrared spectroscopy (FTIR) results showed that hydrogen bonding occurs between the tannic acid (TA) molecule and the collagen.
View Article and Find Full Text PDFPolydopamine Promotes Dentin Remineralization via Interfacial Control.
ACS Biomater Sci Eng
June 2020
Biomineralization has intrigued researchers for decades. Although mineralization of type I collagen has been universally investigated, this process remains a great challenge due to the lack of mechanistic understanding of the roles of biomolecules. In our study, dentine was successfully repaired using the biomolecule polydopamine (PDA), and the remineralized dentine exhibited mechanical properties comparable to those of natural dentine.
View Article and Find Full Text PDFObjective: Previous studies have shown the association between menopause and dyslipidemia. This study was aimed to evaluate the effect of Chinese herbal medicine, tonifying kidney and descending turbidity (TKDT) granule, on serum lipid profiles in postmenopausal women with dyslipidemia.
Methods: A double-blind randomized, placebo-controlled trial was conducted among 104 postmenopausal Chinese women with mild dyslipidemia.