Publications by authors named "Qiaoli Shi"

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide and has become a recognized global health problem. Therefore, the search for new anti-CRC agents or the exploration of new effective drug targets for CRC therapy is urgent. Chloroquine (CQ) is a widely-used antimalarial drug and has shown anti-proliferative effects in CRC.

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The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient's condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. Mechanistic studies indicated that QCT and Mn exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis.

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Background: Epilepsy is a neurological disorder characterized by recurrent seizures, tightly associated with neuroinflammation. Activation of inflammatory cells and molecules in damaged nervous tissues plays a pivotal role in epilepsy. Caffeic acid, one of the most abundant polyphenols in coffee, has shown potent protective effects as a phytomedicine in various neurological disorders.

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Article Synopsis
  • - A significant outbreak of bacterial pith necrosis in tomatoes occurred in August 2023 in Yunnan Province, China, affecting over 40% of the plants in a single greenhouse, causing symptoms like waterlogged rot and wilting of leaves.
  • - The pathogen was isolated using various microbiological techniques, including disinfection, tissue immersion, and culturing on specific agar media, leading to the identification of a strain called Kv4.
  • - Biochemical tests and DNA sequencing revealed strain Kv4’s characteristics, aligning it closely with a known species, confirming its identity through high sequence similarity in the 16S rDNA and other genes.
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Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemisinin resistance. In recent years, significant progress has been made in understanding the mechanism of action (MoA) of artemisinin.

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Background: The pentose phosphate pathway (PPP) plays a crucial role in the material and energy metabolism in cancer cells. Targeting 6-phosphogluconate dehydrogenase (6PGD), the rate-limiting enzyme in the PPP metabolic process, to inhibit cellular metabolism is an effective anticancer strategy. In our previous study, we have preliminarily demonstrated that gambogic acid (GA) induced cancer cell death by inhibiting 6PGD and suppressing PPP at the cellular level.

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Identifying the cellular targets of bioactive small molecules within tissues has been a major concern in drug discovery and chemical biology research. Compared to cell line models, tissues consist of multiple cell types and complicated microenvironments. Therefore, elucidating the distribution and heterogeneity of targets across various cells in tissues would enhance the mechanistic understanding of drug or toxin action in real-life scenarios.

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Triptolide (TPL), a natural product extracted from Tripterygium wilfordii Hook F, exerts potential anti-cancer activity. Studies have shown that TPL is involved in multiple cellular processes and signal pathways; however, its pharmaceutical activity in human colorectal cancer (CRC) as well as the underlying molecular mechanism remain elusive. In this study, the effects of TPL on HCT116 human colon cancer cells and CCD841 human colon epithelial cells are first evaluated.

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  • Nanocarriers can enhance drug delivery for various treatments but face challenges, particularly degradation within endosomes/lysosomes after being taken up by cells.
  • The review discusses advanced methods to improve delivery efficiency by facilitating escape from endosomes/lysosomes and using alternative delivery methods that bypass these pathways.
  • Ultimately, the article suggests innovative design strategies for nanodrug delivery systems to overcome these cellular barriers and improve clinical outcomes in the future.
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  • - Cancer is a complex disease caused by genetic mutations that complicate treatment due to issues like tumor heterogeneity and drug resistance.
  • - A variety of treatment options, including nucleic acids and therapeutic drugs, have been explored, but combining these with nanotechnology is proving to enhance effectiveness against cancer.
  • - The review highlights advancements in using nanomedicine for co-delivering drugs and nucleic acids, discusses challenges in clinical application, and outlines future directions for more effective cancer therapies.
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  • The complexity of serum composition makes it challenging to discover new biomarkers for disease diagnosis and prediction using serum proteomics.
  • Researchers developed a strategy using silica-coated iron oxide nanoparticles to enrich low-abundance proteins, identifying 1,070 proteins, which is double that found by traditional methods.
  • This approach was applied to a collagen-induced arthritis model, revealing 485 differentially expressed proteins, with 323 returning to normal levels after methotrexate treatment, suggesting enhanced understanding of disease mechanisms and better biomarker identification for treatment.
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Calcium phosphate nanoparticles represent promising materials for drug delivery because of its favorable properties, including biocompatibility, biodegradability and strong affinity for binding to nucleic acids (pDNA, siRNA, miRNA, etc.) and therapeutic drugs (cisplatin, carboplatin, paclitaxel, gefitinib, doxorubicin, etc.).

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Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic and further revealed that it might target a class of glutathione -transferases to activate ROS-p38 signaling and induce apoptosis in senescent cells.

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A formal [4 + 2] annulation of diamines and prop-2-ynyl sulfonium salts was developed. This strategy enables efficient access to tetrahydroquinoxalines in excellent yields.

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Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) is a natural compound that exists widely in herbal medicines, such as Fisch, which is used for treating multiple liver diseases, especially in Asia.

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Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism of action (MoA) is not fully understood.

Methods: We used the principle of photo-affinity labeling and click chemistry-based functionalization in the design of a CQ probe and developed a combined deconvolution strategy of activity-based protein profiling (ABPP) and mass spectrometry-coupled cellular thermal shift assay (MS-CETSA) that identified the protein targets of CQ in an unbiased manner in this study.

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There are rarely new therapeutic breakthroughs present for neurodegenerative diseases in the last decades. Thus, new effective drugs are urgently needed for millions of patients with neurodegenerative diseases. Celastrol, a pentacyclic triterpenoid compound, is one of the main active ingredients isolated from Hook.

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Aristolochic acid (AA), mainly derived from herbal and plants, was listed as a human carcinogen class I in 2002. Aristolochic acid nephropathy (AAN) is a rapidly progressive tubulointerstitial nephritis and urothelial cancer caused by AA. However, the targeting molecular mechanisms of AAs-induced nephrotoxicity are largely unclear.

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Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the "best hope for the treatment of malaria" by World Health Organization. With its high potency and low toxicity, the wide use of artemisinin effectively treats the otherwise drug-resistant parasites and helps many countries, including China, to eventually eradicate malaria.

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Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated. We assumed that GA could relieve TGT-induced acute liver injury by regulating liver function-related genes and lipid metabolites. TGT-induced acute liver injury models were constructed and .

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Starch hemostatic agents have been clinically used in surgical hemostasis in recent years. Calcium ion (Ca)-exchange cross-linked porous starch microparticles (CaCPSMs) were prepared as a new hemostatic agent to enhance the hemostatic efficacy. A series of CaCPSMs with varying Ca contents were prepared and characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscope (SEM), and ion content analysis.

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A rapid and sensitive method was established for arsenic (As) speciation based on high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This method was validated for the quantification of four arsenic species, including arsenite (As), arsenate (As), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in cynomolgus macaque plasma. Separation was achieved in just 3.

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The results of a toxicity analysis showed differences from those of the existing experimental data. Therefore, HPLC-ICP-MS was used to analyze the soluble arsenic content at different valences in realgar prepared with water grind processing, which were collected from 3 companies. The results showed that the free arsenic of the 3 companies did not exceed the limit of Chinese Pharmacopoeia.

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