Effects of Psychological Stress on Spontaneous Itch and Mechanical Alloknesis of Atopic Dermatitis.

Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as an intractable itch. Psychological stress has been suggested to play a role in the onset and worsening of AD symptoms. However, the pathophysiological relationships between psychological stressors and cutaneous manifestations remain unclear.

STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma.

Background: Our previous study has revealed that EphA7 was upregulated in patient-derived esophageal squamous cell carcinoma (ESCC) xenografts with hyper-activated STAT3, but its mechanism was still unclear.

Materials And Methods: To assess the association between EphA7 and STAT3, western blotting, immunofluorescence, ChIP assay, and qRT-PCR were conducted. Truncated mutation and luciferase assay were performed to examine the promoter activity of EphA7.

The Alopecia Areata Phenotype Is Induced by the Water Avoidance Stress Test In -Deficient Mice.

We recently discovered a nonsynonymous variant in the coiled-coil alpha-helical rod protein 1 () gene within the alopecia areata (AA) risk haplotype. We also reported that the engineered mice with this risk allele exhibited. To investigate more about the involvement of the gene in AA pathogenesis, we developed an AA model using C57BL/6N gene knockout mice.