Publications by authors named "Qiaofen Qi"
Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which causes significant economic losses to the pig industry worldwide. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. This study was aimed to develop a recombinant human adenovirus type 5 expressing the CSFV E2 gene (rAdV-E2) and evaluate its efficacy in rabbits and pigs.
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- An alphavirus-based DNA vaccine (pSFV1CS-E2) effectively protected pigs from classical swine fever virus (CSFV) through cell-mediated immunity, despite low antibody levels.
- In a mouse model, researchers assessed the vaccine's ability to stimulate immune responses using various assays, including lymphoproliferation and cytokine production.
- The study found that both vaccine versions prompted strong immune responses, with the variant pSFV1CS-E2-UL49 showing even greater enhancement in immune activity due to the addition of pseudorabies virus protein VP22.
Classical swine fever (CSF), which is caused by classical swine fever virus (CSFV), causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. In this study, a recombinant replication-defective human adenovirus expressing the CSFV E2 gene (rAdV-E2) was generated and evaluated for the immunogenicity in rabbits.
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