Publications by authors named "Qiaodong Wei"
Article Synopsis
- The study focuses on how the physical and mechanical properties of red blood cells (RBCs) can change due to various diseases, making it challenging to use these changes for clinical diagnosis.
- Researchers have developed a high-throughput microfluidic technology combined with machine learning to accurately measure properties like shear modulus and viscosity of individual RBCs.
- This new methodology enables the detection of subtle changes in RBC mechanics in response to drugs, potentially providing new disease diagnosis tools based on biophysical markers without the need for labels.
Non-muscle myosin II (NMII) is a force-generating mechanosensitive enzyme that responds to mechanical forces. NMIIs mechanoaccumulate at the cell cortex in response to mechanical forces. It is essential for cells to mechanically adapt to the physical environment, failure of which results in mitotic defects when dividing in confined environment.
View Article and Find Full Text PDFMechanical properties of red blood cells (RBCs) change during their senescence which supports numerous physiological or pathological processes in circulatory systems by providing crucial cellular mechanical environments of hemodynamics. However, quantitative studies on the aging and variations of RBC properties are largely lacking. Herein, we investigate morphological changes, softening or stiffening of single RBCs during aging using an in vitro mechanical fatigue model.
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