Publications by authors named "Qiaodan Ke"
Article Synopsis
- Breast cancer is the leading cause of cancer-related deaths among women globally, with metastasis being a key factor in these fatalities.
- The study investigates the role of the TEA domain transcription factor 4 (TEAD4) in promoting tumor cell adhesion and migration through the regulation of the adhesion molecule Fibronectin (FN1), highlighting its potential links to cancer metastasis.
- Curcumin is shown to reduce the migration and invasion abilities of breast cancer cells by inhibiting TEAD4's interaction with the FN1 promoter, suggesting that targeting the TEAD4-FN1 axis could help mitigate breast cancer metastasis.
Ethnopharmacological Relevance: In traditional Chinese medicine, there is a long history that curcuma longa L is used to treat distending pain of chest and belly, arthralgia of shoulder and arm aggravated by cold. Traditional Chinese medicine holds that breast cancer is caused by cold congelation, stagnation of qi and blood stasis. It is usually treated with some pungent and warm Chinese herbs, such as Curcuma longaL and Curcuma zedoaria (Christm.
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