Equal-Additive-Subtractive Remanufacturing Integrated Laser Directed Energy Deposition with Shot Peening and Machining Induced High Performance of Plunger Rod.

The number of easily destroyed parts with high value is increasing in industry, and green remanufacture engineering is now mainstream in this new and expanding industrial field. Equal-additive-subtractive manufacturing, as a new technology that combines strengthening technology, additive manufacturing, and machining technology has great potential for development in the area of remanufacturing. Aiming at the damage characteristics of a plunger rod, this paper carries out a study about the repair technology by equal-additive-subtractive manufacturing of laser-directed energy deposition and shot peening.

Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable disease involving motor neuron (MN) degeneration and is characterized by ongoing myasthenia and amyotrophia in adults. Most ALS patients die of respiratory muscle paralysis after an average of 3-5 years. Defective autophagy in MNs is considered an important trigger of ALS pathogenesis.

Renewable UV-curable polyester methacrylate/cellulose nanocrystals composite resin for wood waterproof coating.

Low-viscosity UV-curable resins are widely used in industry as they allow for UV curing materials with reduced amounts of reactive diluents to adjust the viscosity. But their mechanical properties and waterproof performance after curing as UV coatings still need to be improved. Here, a series of low-viscosity bio-based UV-curable polyester methacrylates were synthesized through L-lactide (LA) and-caprolactone (CL) monomers.

Brucine inhibits proliferation of glioblastoma cells by targeting the G-quadruplexes in the c-Myb promoter.

The proto-oncogene plays an important role in cell proliferation, and its upregulation affects the development of glioblastomas. G-quadruplexes are secondary DNA or RNA structures that usually form in the promoter region of oncogenes, including , and regulate the expression of these genes. The traditional Chinese medicine, brucine, is a ligand of the G-quadruplexes located in the promoter region of .

Gut microbiota is involved in the alleviation of loperamide-induced constipation by honey supplementation in mice.

Constipation is one of the most common functional gastrointestinal disorders accompanied with intestinal dysbiosis. Laxatives for constipation usually have side effects. Bee honey is a natural food with unique composition, antimicrobial properties, and bifidogenic effect.

β-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species.

Glioblastoma multiforme (GBM) is one of the most aggressive human tumors, and it has a poor prognosis. Temozolomide (TMZ) is the primary alkylating agent used to treat GBM. Nevertheless, a number of GBM patients are resistant to TMZ.