Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice.

Ulcerative colitis (UC), characterized by disrupted intestinal barrier integrity and chronic inflammation, was modeled in mice via dextran sulfate sodium (DSS) induction. This study explored the therapeutic potential of berberine-evodiamine (BBR-EVO), bioactive components of the traditional Chinese medicine Yulian decoction, in DSS colitis. BBR-EVO intervention ameliorated weight loss, diarrhea, colonic shortening, and histopathological damage in colitic mice.

Bacterial-responsive biodegradable silver nanoclusters composite hydrogel for infected wound therapy.

Skin wounds are susceptible to bacterial infections, which hinder healing and extend recovery. Herein, we designed a silver nanoclusters (Ag NCs) composite hydrogel for infected wound treatment via bacterial enzymatic degradation and Ag release. Using biocompatible gelatine and polyethylene glycol as the main components, DNA-templated Ag NCs were covalently linked to a polymer network to obtain the final nanocomposite hydrogel.

Comprehensive transcriptomic analysis of immune-related genes in diabetic foot ulcers: New insights into mechanisms and therapeutic targets.

Background: Diabetic foot ulcers (DFU), affecting a quarter of diabetic patients and leading to high rates of amputation and mortality, pose significant health and economic burdens. Wound healing in DFU is often compromised by chronic inflammation, underscoring the critical role of immune cells. However, the systematic investigation of immune-related genes (IRGs) in DFU pathogenesis remains elusive.

Adherence to preventive treatment for latent tuberculosis infection in close contacts of pulmonary tuberculosis patients: A cluster-randomized controlled trial in China.

Objectives: This study examined adherence rates to tuberculosis preventive treatment (TPT) among close contacts of individuals with pulmonary tuberculosis (PTB) and identified factors associated with TPT adherence in China.

Methods: A multicenter, cluster-randomized, open-label control trial was carried out across three sites involving 34 counties in China. Close contacts of bacteriologically confirmed rifampin and isoniazid-susceptible PTB cases were identified and screened for latent tuberculosis infection (LTBI).

Impact of PD-L1 Gene Polymorphisms and Interactions with Cooking with Solid Fuel Exposure on Tuberculosis.

Introduction: Given that PD-L1 is a crucial immune checkpoint in regulating T-cell responses, the aim of this study was to explore the impact of PD-L1 gene polymorphisms and the interaction with cooking with solid fuel on susceptibility to tuberculosis (TB) in Chinese Han populations.

Methods: A total of 503 TB patients and 494 healthy controls were enrolled in this case-control study. Mass spectrometry technology was applied to genotype rs2297136 and rs4143815 of PD-L1 genes.

An eco-friendly construction of superwetting alginate-based aerogels with self-cleaning performance for multifunctional water treatment.

The increasingly complex oily wastewater has become a severe environmental issue worldwide, calling for the eco-friendly methods toward multifunctionality, high efficiency and sustainability. This work presents a superwetting alginate-based aerogels prepared by a feasible mineralization without the assistance of intermediates. In this strategy, in-situ grown β-FeOOH nanoparticles on whole porous alginate aerogels, not only provides the hierarchical topography and more -OH groups, enhancing underwater oleophobicity (152 ± 4.

Polymorphisms in genes and gene‑smoking interaction are associated with susceptibility to tuberculosis.

Background: Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) are involved in the clearance of (MTB) by macrophages.

Aim: This study aimed to investigate the effects of polymorphisms in the genes and the gene-smoking interaction on susceptibility to TB.

Methods: This case-control study used stratified sampling to randomly select 503 TB patients and 494 control subjects.

A Novel Antithrombocytopenia Agent, , Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.

Background: is a famous traditional Chinese medicine (TCM) used to treat bleeding, rheumatism, lumbago, etc. However, its therapeutic effects and mechanism against thrombocytopenia are still unknown so far. In the study, we investigated the effects of aqueous extracts of (AECRs) against thrombocytopenia and its molecular mechanism.

Building a whole process policy framework promoting construction and demolition waste utilization in China.

The generation of construction and demolition waste (CDW) in China has increased dramatically in recent decades due to the rapid urbanization. Yet there is a very limited utilization of this waste, meaning that there is an urgent need to address this issue in order to reduce the reliance on virgin materials and improve the lived environment in China. This problem contrasts with the EU experience where many member states already exceed an 80% utilization rate of CDW due to extensive policy measures.

Farmers' Adaptive Behaviors to Heavy Metal-Polluted Cultivated Land in Mining Areas: The Influence of Farmers' Characteristics and the Mediating Role of Perceptions.

Heavy metal pollution in cultivated land poses a serious threat to environmental health and farmers' livelihoods. As the direct user of cultivated land, understanding farmers' adaptive behavior to heavy metal pollution, and its influencing factors, can provide insight and information relevant for decision-making, so as to better manage the hazards and risks of heavy metal pollution. We proposed a conceptual framework of "farmers' characteristics-perceptions-adaptive behaviors".

The potential effects and mechanisms of hispidulin in the treatment of diabetic retinopathy based on network pharmacology.

Background: Diabetic retinopathy (DR), one of the most common and severe microvascular complication of diabetes mellitus (DM), is mainly caused by diabetic metabolic disorder. So far, there is no effective treatment for DR. Eriocauli Flos, a traditional Chinese herb, has been used in treating the ophthalmic diseases including DR.

FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer.

Human papillomavirus (HPV)-mediated cervical carcinogenesis is a multistep progressing from persistent infection, precancerous lesion to cervical cancer (CCa). Although molecular alterations driven by viral oncoproteins are necessary in cervical carcinogenesis, the key regulators behind the multistep process remain not well understood. It is pivotal to identify the key genes involved in the process for early diagnosis and treatment of this disease.

Effects of Levistilide A on Hemorheology and Endothelial Cell Injury in Rats with Blood Stasis.

Background: Vascular endothelial cell injury is not only the initiating factor of cardiovascular and cerebrovascular diseases but also the essence of blood stasis. Levistilide A (LA), a natural component isolated from the traditional Chinese herb, Hort, has traditional effects on improving blood circulation and removing stasis. In this study, the effects and potential mechanisms of LA in the rat model of blood stasis and the mechanism in endothelial cell injury have been explored.

The Effect of Melatonin on OCT4 Expression and Granulosa Cell Growth in Female Mice.

Melatonin is mainly secreted by the pineal gland as a neurotransmitter. Moreover, melatonin is also produced by the ovary and plays important roles in female reproduction. However, it is unclear whether melatonin has any effect on the transition from the preantral follicle to the early antral follicle.

Mechanisms of OCT4 on 3,5,3'-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice.

Octamer-binding transcription factor 4 (OCT4) regulates the pluripotency of stem cells and also plays important roles in granulosa cells growth, which is regulated by follicle-stimulating hormone (FSH). Thyroid hormone (TH) is important for the development and maturation of follicles and the maintenance of various endocrine functions. Although 3,5,3'-triiodothyronine (T3) enhances the effects of FSH on the regulation of the growth of granulosa cells and development of follicles, it is unclear whether and, if so, how TH combines with FSH to regulate OCT4 expression in granulosa cells during the preantral to early antral transition stage.

Effects of thyroid hormone on ovarian cell apoptosis in the rat.

Follicle development is a complicated process regulated by thyroid hormone (TH). TH dysregulation is associated with reproductive disorders; however, the mechanism underlying these relationships remains unclear. Glucose-related protein 78 (GRP78) is a well-characterised endoplasmic reticulum stress protein related to ovarian cell apoptosis.

An innovative strategy for synchronous treatment of combined heavy metal and organic pollutants through polysaccharide gel encapsulating S.

In many industrial fields, treatment of composite contaminations involving inorganic heavy metal ions and organic pollutants simultaneously remains a tremendous challenge. In this paper, an innovative strategy based on the gelation process of Sodium Alginate (SA) was proposed for synchronous treatment of composite pollutants. Through a pre-gelation step, SA gel balls encapsulated with S (SA/S gel) were formed and immersed into polluted solutions containing Pb/Cd and Cd/dye.

Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice.

As a member of the POU (Pit-Oct-Unc) transcription factor family, OCT4 (Octamer-binding transcription factor 4) is associated with the cellular proliferative. However, the roles of OCT4 in regulating the transition from preantral follicle to early antral follicle are still remains unclear. To evaluate the effect of OCT4 on cellular development in ovary, mice were injected with eCG or granulosa cells were co-cultured with FSH .

Roles of different n-3/n-6 PUFA ratios in ovarian cell development and steroidogenesis in PCOS rats.

Polycystic ovary syndrome (PCOS) is a complex and common endocrine disorder characterized by hyperandrogenism, which is accompanied by follicle growth arrest at the small antral stage, minimal granulosa cell proliferation, and chronic anovulation. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Although PUFAs play an important role in the regulation of female reproduction, their role in ovarian development in PCOS is still unclear.

Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary.

Although thyroid hormone (TH) plays important roles in regulating ovarian development, the mechanism are still unclear. Cytochrome P450 lanosterol 14α-demethylase (CYP51) is a key enzyme in sterols and steroids biosynthesis that involved in folliculogenesis and oocyte maturation, which is regulated by follicle stimulating hormone (FSH). However, the effect of TH on CYP51 expression in ovarian cells is unclear.

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation.

Exposure to early adversity increases vulnerability to psychiatric disorders in later life. Microglia-mediated inflammation has been linked to psychopathology, so such inflammation may be a target for treating depression. Using a model of depression involving adolescent male C57BL/6J mice subjected to maternal separation, we explored whether using minocycline to mitigate inflammation can alleviate depression-like behaviors.