link to poor prognosis and immune infiltration of head and neck squamous cell carcinomas.

Background: Head and neck squamous cell carcinomas (HNSCs) are a diverse collection of tumors that originate in the oral cavity, pharynx, and larynx and pose a severe threat to human health, contributing to a fast-rising burden of cancer morbidity and mortality. The search for prognostic biomarkers of HNSC has been a hot topic. Spindle and kinetochore-associated () complex, including three members , which stabilize the spindle microtubules at the kinetosite during mitosis metaphase, has been demonstrated to be associated with poor prognosis of different cancers.

ROP Prediction Method Based on PCA-Informer Modeling.

Increasing the rate of penetration (ROP) is an effective means to improve the drilling efficiency. At present, the efficiency and accuracy of intelligent prediction methods for the rate of penetration still need to be improved. To improve the efficiency and accuracy of rate of penetration prediction, this paper proposes a ROP prediction model based on Informer optimized by principal component analysis (PCA).

Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis.

Introduction: Metastasis is an important cause of high mortality and lethality of oral cancer. Fusobacterium nucleatum (Fn) can promote tumour metastasis. Outer membrane vesicles (OMVs) are secreted by Fn.

Analysis of the Efficacy and Safety of Pulpitis Treated with Different Root Canal Flushing Fluids Based on VAS and Temporomandibular Joint Function.

Pulpitis is one of the common diseases indicated by the department of stomatology that is located in the tooth and contains abundant nerve vessels. In order to evaluate the pain degree and functional recovery of patients after treatment by visual analogue pain scale (VAS) and temporomandibular joint function score, a retrospective analysis was performed on 128 patients diagnosed with pulpitis who received root canal treatment in the department of stomatology from January 2020 to March 2021. The results show that 3%NaClO combined with 0.

Poor Prognosis of Oral Squamous Cell Carcinoma Correlates With ITGA6.

Objectives: Oral cancer is the ninth most common cancer worldwide and a leading cause of cancer-related death. Oral squamous cell carcinoma (OSCC) accounts for 90% of all oral cancers. Autophagy is a conserved essential catabolic process related to OSCC.

Development of Ferroptosis-Associated ceRNA Network in Periodontitis.

Objectives: Periodontitis is a chronic inflammatory illness that may lead to tooth loosening and even loss, and its pathogenesis is not fully understood. Ferroptosis is an iron-dependent, regulated cell death. The present study aims to find the key ferroptosis-related genes (FRGs) in periodontitis and develop an mRNA-miRNA-lncRNA network to deeply explore the pathogenesis of periodontitis.

Circular RNA profiles of osteoarthritic synovium.

Purposes: To identify the circular RNA (circRNA) expression profile in the synovium of patients with osteoarthritis (OA) and explore their potential regulatory mechanism.

Methods: Transcriptome high-throughput sequencing was used to detect the expression profiles of circRNA and mRNA. We performed real-time PCR for the validation of circRNAs and used bioinformatics analysis to predict their possible biological functions.

Outer Membrane Vesicles From Switch M0-Like Macrophages Toward the M1 Phenotype to Destroy Periodontal Tissues in Mice.

Periodontitis is a chronic inflammatory oral disease that affects nearly 50% of all adults. () is known to be involved in the formation and development of periodontitis. Outer membrane vesicles (OMVs) harboring toxic bacterial components are continuously released during growth and regulate the extent of the inflammatory response by controlling the functions of immune and non-immune cells in tissues.

Green returns to education: Does education affect pro-environmental attitudes and behaviors in China?

Using microdata from the Chinese General Social Survey (CGSS 2010), this paper investigates whether there are green returns to education in China, where educational attainment promotes pro-environmental attitudes and behaviors. We establish causality by exploiting the exogenous variation induced by the implementation of the Compulsory Schooling Law (CSL) in China. We find evidence that educational attainment is associated with higher levels of pro-environmental attitudes and behaviors, and these estimates are robust to various robustness checks.

Inhibition of yes-associated protein dephosphorylation prevents aggravated periodontitis with occlusal trauma.

Background: Occlusal trauma can aggravate periodontitis, but the mechanism remains unclear. Yes-associated protein (YAP), a mechanical stressor protein, may play an important role in this process.

Methods: Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) were applied to detect the expression of YAP and inflammatory factors in patients with periodontitis accompanied with or without occlusal trauma.

[Clinical efficacy of the fine needle aspiration of the cell block in the diagnosis of parotid gland masses].

Objective: To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses.

Methods: Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks.

[Morphological features and analysis of the nerve fibers in the periodontal ligament of dogs].

Objective: To identify the properties of nerve fibers of dogs by immunohistochemical staining method.

Methods: Intact bone blocks above the inferior alveolar nerve canal were cut from the medial of the second premolar to the distal of the third premolar of healthy adult Beagle dogs of 18 months, embedded to make hard tissue sections, stained with S100 and neurofilament protein (NFP) antibodies, and finally observed the nerve distribution under the microscope.

Results: The distribution of S100 positive tissue in the periodontal ligament of dogs showed the following patterns: bundles of densely gathered rings with different diameters, filaments accompanied by lumens, free endings and deep-dyeing oval lamellasome.

Large Doses of Propranolol for the Treatment of Infantile Cephalic and Facial Hemangiomas: A Clinical Report of 38 Cases.

Objective: Infantile cephalic and facial hemangiomas (IHs) are common and histologically benign vascular lesions in infants. This study investigates the clinical effect of using large doses of Propranolol for the treatment of IHs.

Study Design: This study contains 38 patients with IHs.

Analysis of curricular reform practices at Chinese medical schools.

Background: A comprehensive search of the literature published between 2001 and 2010 was performed to gain a greater understanding of curricular reform practices at Chinese medical schools.

Summary: There were 10,948 studies published between 2001 and 2010 that were retrieved from the database. Following preliminary screening, 76 publications from 49 different medical schools were selected.

Curriculum reform at Chinese medical schools: what have we learned?

Introduction: Curriculum reform at Chinese medical schools has attracted a lot of attention recently. Several leading medical schools in China have undergone exploratory reforms and in so doing, have accumulated significant experience and have made considerable progress.

Methods: An analysis of the reforms conducted by 38 Chinese medical colleges that were targeted by the government for upgrade was performed.

A snapshot of the status of problem-based learning (PBL) in Chinese medical schools.

Introduction: In North America, where it was born, problem-based learning (PBL) has seen dips and rises in its popularity, but its inherent strengths have led to its spread to medical schools all over the world. Although its use at medical schools in some Western countries has already been examined, no one has looked at its status in many other countries, including China. The aim of this study is to determine the number of schools currently using PBL in China, the degree to which they use it, and the reasoning behind such usage.

[In vitro effect of banxiaxiexin-decoction and different combinations on the metabolic activities of baicalin and baicalein in rat liver microsomes].

Objective: To study the metabolism kinetics of baicalin and baicalein from Scutellaria baicalensis in rat liver microsomes and compare the effect of Banxiaxiexin-Decoction with different combinations on the metabolic activities of the flavonoids (baicalin and baicalein).

Methods: An UPLC method was developed for determination of baicalin and baicalein in rat liver microsomes incubation system. The effect of Banxiaxiexin-Decoction and different combinations (pungent-swelling group, bitter-descending group, sweet-invigorating group) on the metabolic activities of the flavonoids was investigated by vivo-induction and vitro-incubation method.

[In vitro effect of Banxiaxiexin Tang and different conbinations on hepatic CYP450 in rats].

To study the effect of Banxiaxiexin Tang and different conbinations on CYP450 in rat liver microsomes, from the point of liver metabolism, evaluate significance of Banxiaxiexin Tang compatibility. The rats were randomly divided into five groups: Banxiaxiexin Tang group, pungent-swelling group, bitter-descending group, sweet-invigorating group and control group, which were all given decoction by gavage. Using liver microsomes in vitro incubation method, probe substrate were incubated and their metabolites was detected by ultra-high performance liquid chromatography, then was calculated metabolic rate to reflect the drug-treated liver microsomes CYP2C6, CYP2E1, CYP3A1/2 activity.