Identifying the unmet supportive care needs, with concomitant influencing factors, in adult acute leukemia patients in China.

Purpose: To understand the supportive care needs (SCNs), with associated influencing factors, related to five unmet need dimensions in adult Acute Leukemia (AL) patients, in China.

Methods: This multi-center cross-sectional study enrolled 340 pathologically confirmed adult, Chinese AL patients who were requested to complete a self-reported questionnaire, detailing demographic information, general status and physical functions, and Supportive Care Needs Survey-Short Form 34 (SCNS-SF34), revealing their unmet SCNs. The variables were statistically analyzed.

Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.

Ent-kaurane diterpene compounds have attracted considerable attention in recent years due to its antitumor, antibacterial, and antiviral activities. However, the clinical development of natural kaurane diterpenes, for example, oridonin for cancer therapy has been hampered by its relatively moderate potency, limited bioavailability. Herein, we report a newly synthetic analog of natural ent-kaurane diterpene, DS2, which exhibits significantly improved activity of antiproliferation against various cancer cell lines relative to oridonin.

[Data Processing Method of Asymmetric Spatial Heterodyne Interferogram for Wind Measurement].

By using doppler asymmetric spatial heterodyne spectroscopy and doppler effect, the wind speed can be achieved through detecting the interferogram of airglow in the upper atmosphere. This paper mainly analyses the data processing method of the interferogram and then derive the interferometer phase in order to get the wind speed. Comparing with the traditional spatial heterodyne spectroscopy, not only the noise and error of the system should be taken into consideration, but the window function that used to isolate the spectrum has a great influence during the data processing.

[Study on Asymmetric Spatial Heterodyne Spectroscopy].

Restrictive relationship exists between spectral resolution, spectral range and number of pixels of traditional Spatial Heterodyne Spectroscopy (SHS). The main difference between Asymmetric Spatial Heterodyne Spectroscopy (ASHS) and SHS accelerates the space of one grating from the beamsplitter. It greatly increases spectral resolution while system parameters remain unchanged.

ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women.

Unlike its reported role in the cardiovascular diseases, little information is available for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in the cerebrovascular function. We investigated the different effects of ALDH2 genotypes on the risk of cerebral infarction between the genders, because different genders had different smoking and/or dinking status which are also risk factors for cerebral infarction. 247 healthy Chinese Han people (controls, group 1), 287 Chinese Han male patients with cerebral infarction (group 2), and 82 Chinese Han female patients with cerebral infarction (group 3) were involved in this study.

Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.

The presence of cancer stem-like cells (CSCs) has been demonstrated to be associated with tumor metastasis, chemoresistance, and rapid recurrence of various tumors. The impact of CSC-related markers in the metastasis and prognosis of ovarian cancer has not been well established. In this study, the protein expression of musashi-1 and ALDH1 was measured using immunohistochemistry.

Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus.

Recently, many researchers have reported that the genetic polymorphisms of CYP2C19 may account for the interpatient variability of the clinical course in cancers including primary liver cancer (PLC). Besides the genetic polymorphisms of CYP2C19, hepatitis viruses (HV, including HAV, HBV, HCV, HDV, HEV, especially HBV and/or HCV) also account for the interpatient variability of the clinical course in PLC. This research covered the above two factors and divided the patients with PLC into two groups (one group with HBV infection and another without any HV infection) to find out whether the genetic polymorphisms of CYP2C19 have different effects in the progressing of PLC in different groups of patients.

Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.

In this study, the protein levels of Axl and prostasin in malignant neoplasms of the ovary and their clinicopathologic significance were investigated. The protein levels of Axl and prostasin in ovarian adenocarcinomas (n = 80), serous cystadenoma (n = 15), mucinous cystadenomas (n = 15), and normal ovary tissues (n = 10) were measured using immunohistochemistry. The percentage of Axl-positive cases was significantly higher in ovarian adenocarcinoma (61.

[The molecular epidemiology characteristics of norovirus in environment and clinical samples in Guangzhou from 2009 to 2011].

Objective: To investigate the molecular epidemiological characteristics of norovirus in Guangzhou from 2009 to 2011.

Methods: A total of 183 water samples, 1162 seafood samples and 1066 diarrhea stool specimens were collected from January 2010 to May 2011, June 2009 to June 2011 and July 2009 to December 2010 respectively in Guangzhou. Norovirus was detected by real time reverse transcript-PCR (qRT-PCR).

An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water.

A convenient and practical method for the synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines has been developed via a three-component, one-pot reaction from aldehydes, malononitrile and S-alkylisothiouronium salts in water at room temperature. A series of polysubstituted pyrimidines were prepared by this method in moderate to excellent yields. In addition, two kinds of pyrimidine-fused heterocyclic derivatives with potential pharmacological activity were constructed from our 2-alkylthio-4-amino-5-cyano-6-arylpyrimidines.

[Inversion of the lake total nitrogen concentration by multiple regression kriging model based on hyperspectral data of HJ-1A].

The content of total nitrogen in the waters is an important index to measure lake water quality, and the technique of remote sensing plays a large role in quantitatively monitoring the dynamic change and timely grasping the status of lake pollution. Taking Chaohu as an example, quantitative inversion models of total nitrogen were established by multivariable regression Kriging under analyzing of an correlation between total nitrogen and chlorophyll-a or suspended solids by HIS hyperspectral remote sensing data of HJ-1A satellite. The result shows that the correlation of 0.

Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines.

On the basis of combination strategy, a novel series of EGFR inhibitors were designed and synthesized by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay in three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Two compounds (11d and 11f) were found more potent against all three cell lines and five compounds (11a, 11d-11g) were found more potent against both MDA-MB-468 and SK-BR-3 than Lapatinib.

[Radiometric calibration of LCTF-based multispectral area CCD camera].

Multispectral area CCD camera based on liquid crystal tunable filter (LCTF) is a new spectral imaging system, which could record image of one wavelength on the area CCD by utilizing electrically controlled birefringence of liquid-crystal and interference principle of polarized light. Because of the special working principle of LCTF and frame transfer area CCD, the existing radiometric calibration method can not meet the precision need of remote sensing application if it is used for LCTF-camera. An improved radiometric calibration method is proposed, in which the camera performance test and calibration experiment are carried out relying on the devices of integrating sphere and standard detector, and the absolute calibration coefficient is calculated via correcting frame transfer smear and improving data process algorithm.

[Study on the inhibitory effect of RNA interference on replication of dengue virus].

To investigate the inhibitory effect of RNA interference (RNAi) on dengue virus I (DENV-1) replication. Small interfering RNA (siRNA) against the PreM gene of dengue virus was synthesized and transfected into C6/36 cells with liposome, which was then attacked by DENV-1 virus. The antiviral effect of siRNA was evaluated by cytopathic effect (CPE), the cell survival rate measured by MTT, and virus RNA quantified by real-time RT-PCR.

[Study on calibration method of spatial heterodyne spectrometer].

Spatial heterodyne spectroscopy (SHS) is a novel method for hyperspectral analysis, but the calibration methods have not been thoroughly studied. The present paper gives some basic theories of SHS, and investigates the laboratory calibration methods, including spectral calibration and radiometric calibration. According to emission lines and the relation between detector size and system bandwidth, we designed the spectral calibration plan for SHS, which uses tunable laser and halogen lamp.

[Data processing for interferogram of spatial heterodyne spectrometer].

Spatial heterodyne spectroscopy (SHS) is a new spectroscopic technique which can achieve high spectral resolution. The basic concepts of spatial heterodyne spectrometer was described. A method of data processing for interferogram of spatial heterodyne spectrometer was presented based on its characteristics.

Sequence-related amplified polymorphism, an effective molecular approach for studying genetic variation in Fasciola spp. of human and animal health significance.

In the present study, a recently described molecular approach, namely sequence-related amplified polymorphism (SRAP), which preferentially amplifies ORFs, was evaluated for the studies of genetic variation among Fasciola hepatica, Fasciola gigantica and the "intermediate" Fasciola from different host species and geographical locations in mainland China. Five SRAP primer combinations were used to amplify 120 Fasciola samples after ten SRAP primer combinations were evaluated. The number of fragments amplified from Fasciola samples using each primer combination ranged from 12 to 20, with an average of 15 polymorphic bands per primer pair.

[Design of hyperspectral imaging system based on LCTF].

A new compact lightweight imaging system for hyperspectral imaging is described. The system can be thought of as the substitute for traditional mechanical filter-wheel sensor. The system is based on different techniques.

[Accuracy analysis on a sort of polarized measurement in remote sensing].

Angular error of polarizer in polarimetric measurement is an important element affecting the measurement accuracy of degree of polarization, so angular error of polarizer should be considered in remote sensing of high-accuracy quantitative polarization. Simulation study shows that polarimetric measurement is relative to the polarization state (polarization angle or degree of polarization) of incident light in a specific measurement system of polarization. In the measurement mode of polarizer setting (0 degree, 60 degrees, 120 degrees), there is a maximum error of polarization measurement at the 0 degree or 180 degrees polarization angle while a minimum error at the 30 degrees, 90 degrees and 150 degrees polarization angle; In the measurement mode of polarizer setting (0 degree, 45 degrees, 90 degrees), there is a maximum error of polarization measurement near the 45 degrees polarization angle while a minimum error at the 0 degree, 90 degrees and 135 degrees polarization angle.