Publications by authors named "Qiao-Xi Xia"
Cell Commun Signal
March 2022
Article Synopsis
- - Background studies show that the kappa opioid receptor (KOR) might be crucial in understanding and treating esophageal squamous cell carcinoma (ESCC), but its specific effects on tumor progression are not fully known.
- - The research compared KOR gene expression in cancerous vs. normal tissues, revealing lower KOR levels linked to worse survival rates; experiments indicated that lowering KOR increased cancer cell growth, spread, and invasion abilities.
- - Mechanistically, reduced KOR activates the PDK1-AKT signaling pathway, facilitating tumor invasion and changes in the cytoskeleton, evidenced by alterations in protein interactions and cellular structures during the tests conducted in both lab and animal models.
