Publications by authors named "Qiao-Wen Chen"
Modulating oxidative stress and neurogenic inflammation: the role of topiramate in migraine treatment.
Front Aging Neurosci
October 2024
Migraine is a chronic, recurrent neurovascular disorder characterized by episodes closely associated with neurovascular hypersensitivity. Oxidative stress can worsen the hypersensitive state of the central nervous system, which in turn can trigger pro-inflammatory factors that result in neurogenic inflammation. Topiramate is frequently used as a preventative measure for migraines, but there is currently little empirical data to support its efficacy through pathways related to neurogenic inflammation and oxidative stress.
View Article and Find Full Text PDFArticle Synopsis
- The study explored chrysophanol's impact on HepG2 liver cancer cells, assessing its effects through various biological assays.
- Chrysophanol significantly inhibited cell growth and migration at higher concentrations (75-100 μmol/L) while altering key protein expressions associated with cell death.
- The findings suggest chrysophanol may be a promising therapeutic agent for treating liver cancer, highlighting its potential role in cancer therapy.