Publications by authors named "Qiao Zi Lin"
Influenza is an acute respiratory infection caused by the influenza virus, and vaccination against influenza is considered the best way to prevent the onset and spread. MDCK (Madin-Darby canine kidney) cells are typically used to isolate the influenza virus, however, their high tumorigenicity is the main controversy in the production of influenza vaccines. Here, MDCK-C09 and MDCK-C35 monoclonal cell lines were established, which were proven to be low in tumorigenicity.
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- Lipogenesis in porcine adipocytes is regulated by transcription factors ChREBP and SREBP-1c in response to glucose and insulin, with ChREBP primarily mediating glucose-induced lipogenesis.
- When ChREBP is silenced, glucose-induced lipogenesis drops by about 70%, while insulin-induced lipogenesis remains unchanged, revealing distinct pathways for these two stimuli.
- LXRα also plays a role in promoting lipogenesis, potentially via SREBP-1c, as it enhances lipogenesis when both ChREBP and SREBP-1c activities are inhibited, indicating that LXRα can directly mediate glucose- and insulin-induced lipogenesis.
Glucose is a substrate for fatty acid synthesis, and induces lipogenesis and expressions of lipogenic genes. It was proposed that transcriptional factor ChREBP, LXRα and SREBP-1c are key mediators in lipogenesis induced by glucose, however the underlying mechanism remains unclear in porcine adipocytes. In this study, glucose stimulated lipogenesis and expressions of ChREBP, LXRα, SREBP-1c and lipogenic genes FAS and ACC1 in primary porcine adipocytes.
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