Recycling Polyester and Polycarbonate Plastics with Carbocation Lewis Acidic Organocatalysts.

The effective management of plastic waste is critical for environmental sustainability. This work explores the use of carbocation catalysts for the recycling of common polyesters and polycarbonates through alcoholysis. We demonstrate complete depolymerization of end-of-life materials and investigate the relationship between the catalytic reactivity and the structural features of the carbocation compounds, including the cations and their counteranions.

Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination.

Background: Gastrodin, an important component of traditional Chinese medicine, is gaining interest because of its anti-tumor effects. Ferroptosis is a new mode of cell death, which has emerged as a promising target for colorectal cancer (CRC) treatment. This research investigates the action mechanism of gastrodin on the process of CRC by inducing ferroptosis.

A portable photoelectrochemical aptasensor based on voltage-resolved dual-signal output for the determination of chloramphenicol.

Developing a ratiometric photoelectrochemical (PEC) aptasensor that can produce cathode-anode dual photocurrent signals is still a great challenge. Herein, we report a novel portable voltage-resolved ratiometric PEC aptasensor for the determination of chloramphenicol (CAP) with a digital multimeter (DMM) and voltage and current signal generator (VCSG) readout. Ru(bpy)-BiOBr heterojunction was employed as the only photoactive material, which is switched between type II and Z - scheme by varying the bias voltage (+0.

PROKR2 mutations and SPRY4 variants with uncertain significance in a Kallmann syndrome family: Incomplete penetrance.

Kallmann syndrome is a rare genetic disease characterized by the idiopathic hypogonadotropic hypogonadism with hyposmia or anosmia, which exhibits considerable heterogeneity in genotype and phenotype. Herein, we reported a 32-year-old male patient with Kallmann syndrome in a family associated with heterozygous mutations in PROKR2 and SPRY4 genes. The genotyping results indicated PROKR2 mutations and SPRY4 variants of uncertain significance, which might be incompletely penetrant in this family.

Strategy of constructing unsaturated bond on hexagonal pore MXene through titanium vacancy defects realizes antioxidant stable storage of potassium-ions in neutral aqueous system.

In order to solve the key problem that MXene is easy to oxidize in aqueous environment, resulting in poor long cycle stability of energy storage devices. In this work, a defect control strategy was used to induce the formation of unsaturated coordination bonds on the surface of titanium vacancy defect hexagonal pore MXene. Under the premise of ensuring the storage of potassium-ions with high energy density, hexagonal pore MXene has achieved the effect of oxidation resistance and long cycle stability in neutral aqueous supercapacitors.

Integrated in vitro, in silico, and in vivo approaches to elucidate the antidiabetic mechanisms of Cicer arietinum and Hordeum vulgare extract and secondary metabolites.

Diabetes mellitus is a group of metabolic disorders that can lead to severe health problems, and the current treatments often have harmful side effects. Therefore, there is a growing interest in discovering new antidiabetic drugs with fewer adverse effects, and natural products are a promising source for this purpose. Cicer arietinum and Hordeum vulgare are plants with high levels of phytochemicals that have been shown to have therapeutic properties.

From adhesion to invasion: the multifaceted roles of lipoproteins.

Tuberculosis (TB) is caused by , which poses a significant threat to human health. Lipoproteins are predominantly found in the cell wall during infection of the invading host. The cell wall interacts closely with the host cell in direct contact.

Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by systemic inflammation with a high short-term mortality rate. Syndecan-1 (SDC-1) can independently predict the 90-day mortality of patients with septic shock. However, the role of SDC-1 in ACLF remains unknown.

Photocatalytic Conversion of Polyester-Derived Alcohol into Value-Added Chemicals by Engineering Atomically Dispersed Pd Catalyst.

Photoreforming presents a promising strategy for upcycling waste polyester-derived alcohol into valuable chemicals. However, it remains a great challenge due to its low performance and unsatisfactory selectivity toward high-value C products. Here, we report the highly efficient and selective conversion of ethylene glycol (EG, a monomer of polyethylene terephthalate (PET)) to glycolaldehyde using atomically dispersed Pd species supported on TiO catalyst.

Elements Doping Strategy for Improving the Thermoelectric Properties of g-CN/SWCNT Composite Films.

Optimizing carrier concentration and transport has been demonstrated to be a practical strategy to improve the thermoelectric efficacy of single-walled carbon nanotube (SWCNT)-based composite films, which have potential application in self-powered wearable electronics. In this study, nonmetallic heteroatoms (boron, sulfur, and phosphorus) are selected to dope g-CN to adjust the energy band structure for fabricating g-CN/SWCNT with high thermoelectric performance. Heteroatom doping of g-CN improves the energy band structure and mobility of g-CN, which promotes the carrier transport between g-CN and SWCNT and optimizes the carrier mobility and concentration of the composite, substantially improving both the Seebeck coefficient () and the electrical conductivity (σ) of g-CN/SWCNT.

The reliability and validity of the Chinese version of premenstrual dysphoric disorder questionnaire for DSM-5.

Objective: Premenstrual dysphoric disorder (PMDD) seriously affects women's work and life, and early screening and diagnosis of PMDD can improve the quality of life of potential PMDD patients. The Premenstrual Dysphoric Disorder Questionnaire for DSM-5 (CTDP-DSM-5) is a validated screening tool for PMDD based on the DSM-5. This study intends to conduct reliability testing and validity evaluation of the scale after translation and revision in Chinese women.

Differential ratiometric molecularly imprinted electrochemical method for methyl-parathion and carbendazim in foods.

Non-specific adsorption of interferents on molecularly imprinted polymer (MIP) membranes bottlenecks their selective recognition to templates. Herein, we reported an improved differential MIP strategy to correct such adverse effect for determining carbendazim (CBZ) and methyl-parathion (MP) in food samples. MIP membranes of CBZ and MP were prepared using mixed functional monomers of β-cyclodextrin and thionine with synergistic recognition selectivity.

A BRAF-activated noncoding RNA attenuates clear cell renal cell carcinoma via repression of glucose-6-phosphate dehydrogenase.

Clear cell renal cell carcinoma (ccRCC) is a disease rooted in metabolic disorders, distinguished by abnormally high activity of glucose 6-phosphate dehydrogenase (G6PD). G6PD serves as a key rate-limiting enzyme in the pentose phosphate pathway. Meanwhile, BRAF-activated noncoding RNA (BANCR) has emerged as a crucial regulatory factor linked to various cancers.

Untwisting Strategy of MOF Nanosheets in Ultrathin Film Membrane for High Molecular Separation Performance.

Oriented 2D metal-organic framework (MOF) membranes hold considerable promise for industrial separation processes. Nevertheless, the lattice misalignment caused by the twisted stacking of 2D nanosheets reduces the in-plane pore size and exerts a significant impact on the membrane separation performance. Precisely regulating the stacking pattern of oriented 2D MOF membranes remains a significant challenge.

Selective Liquid Chemical Production in Waste Polyolefin Photorefinery by Controlling Reactive Species.

Photocatalytic upcycling of waste polyolefins into value-added chemicals provides promise in plastic waste management and resource utilization. Previous works demonstrate that polyolefins can be converted into carboxylic acids, with CO as the final oxidation product. It is still challenging to explore more transformation products, particularly mild-oxidation products such as alcohols, because of their instability compared with polymer substrates, which are prone to oxidation during catalytic reactions.

Exploring Surface State and Exciplex Dominated Aggregation Induced Electrochemiluminescence of Graphene Quantum Dots Prepared via Electrochemical Exfoliation.

Graphene quantum dots (GQDs) have emerged as promising materials for electrochemiluminescence (ECL) applications due to their unique optical and electronic properties. In this study, GQDs were synthesized via electrochemical exfoliation of graphite in a constant current density mode, enabling scalable production with controlled size and surface functionalization. GQDs-4 and GQDs-20, synthesized at applied current densities of 4 mA/cm and 20 mA/cm to the graphite electrode, respectively, were investigated on roles of surface states and exciplex dominated aggregation-induced emission (AIE) in their ECL performance.

Machine learning models for predicting postoperative peritoneal metastasis after hepatocellular carcinoma rupture: a multicenter cohort study in China.

Background: Peritoneal metastasis (PM) after the rupture of hepatocellular carcinoma (HCC) is a critical issue that negatively affects patient prognosis. Machine learning models have shown great potential in predicting clinical outcomes; however, the optimal model for this specific problem remains unclear.

Methods: Clinical data were collected and analyzed from 522 patients with ruptured HCC who underwent surgery at 7 different medical centers.

Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk.

The body weight-based thrombolytic medication strategy in clinical trials shows critical defects in recanalization rate and post-thrombolysis hemorrhage. Methods for perceiving thrombi heterogeneity of thrombolysis resistance is urgently needed for precise thrombolysis. Here, we revealed the relationship between the thrombin heterogeneity and the thrombolysis resistance in thrombi and created an artificial biomarker-based nano-patrol system with robotic functional logic to perceive and report the thrombolysis resistance of thrombi.

Internet-enhanced continuity of care reduces postoperative complications and improves outcomes in pediatric strabismus surgery.

Objective: To explore the application value of Internet Family Engagement Continuum of Care in strabismus ambulatory surgery and evaluate its impact on postoperative complications, children's quality of life, and parental satisfaction.

Methods: A retrospective analysis was conducted on the clinical data of 257 children who underwent strabismus ambulatory surgery in our hospital from February 2022 to December 2023. The children were divided into a control group (n=149), which received routine nursing services and telephone follow-up, and an observation group (n=108), which received Internet Family Engagement Continuum of Care through a mobile medical platform.

SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC), a predominant subtype of renal cell carcinoma, significantly contributes to the heightened morbidity and mortality in individuals diagnosed with urologic tumors. The challenges posed by high malignancy at the initial diagnosis of ccRCC, therapeutic resistance, and unfavorable patient prognosis remain largely unresolved. Our findings indicate that SEPT5 is upregulated in ccRCC and this upregulation is associated with an adverse prognosis for ccRCC patients.

Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells.

ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism. Increasing evidence suggests that ASS1 is commonly dysregulated in the tumor microenvironment, promoting tumor cell metastasis and infiltration. With a deeper understanding of tumor metabolic reprogramming in recent years, the impact of ASS1 dysregulation on abnormal tumor metabolism has attracted growing interest among researchers.

Integrated proteogenomic characterization of ampullary adenocarcinoma.

Ampullary adenocarcinoma (AMPAC) is a rare and heterogeneous malignancy. Here we performed a comprehensive proteogenomic analysis of 198 samples from Chinese AMPAC patients and duodenum patients. Genomic data illustrate that 4q loss causes fatty acid accumulation and cell proliferation.

Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data.

Alzheimer's disease is an irreversible central neurodegenerative disease, and early diagnosis of Alzheimer's disease is beneficial for its prevention and early intervention treatment. In this study, we propose a novel framework, FusionNet-ISBOA-MK-SVM, which integrates a fusion network (FusionNet) and improved secretary bird optimization algorithm to optimize multikernel support vector machine for Alzheimer's disease diagnosis. The model leverages multimodality data, including functional magnetic resonance imaging and genetic information (single-nucleotide polymorphisms).

Selective Recycling of Mixed Polyesters via Heterogeneous Photothermal Catalysis.

The selective recycling of mixed plastic wastes with similar structural units is challenging. While heterogeneous catalysis shows potential for selective recycling, challenges such as complex mass transfer at multiphase interfaces and unclear catalytic mechanisms have slowed progress. In this study, a breakthrough in recycling mixed polyester wastes is introduced using heterogeneous photothermal catalysis.

Mangiferin and EGCG Compounds Fight Against Hyperlipidemia by Promoting FFA Oxidation via AMPK/PPAR.

Hyperlipidemia is a critical risk factor for obesity, diabetes, cardiovascular diseases, and other chronic diseases. Our study was to determine the effects and mechanism of mangiferin (MF) and epigallocatechin gallate (EGCG) compounds on improving hyperlipidemia in HepG2 cells. HepG2 cells were treated with 0.