Anomalously Large Luminescence Modulation Induced by Trace Lanthanide Impurities in Alloyed Upconversion Nanocrystals.

Achieving precise control over emission characteristics, such as wavelength and lifetime, is critical to unlocking the full potential of luminescent nanomaterials for diverse applications. In this work, we present a strategy for fine-tuning the optical properties of upconversion nanocrystals by engineering parts-per-million (ppm)-doping-level lanthanide impurities. We show that even trace impurities (∼10 ppm, fewer than 10 atoms per nanocrystal), which are only a hundredth of the conventionally studied doping levels and were previously considered negligible, serve as efficient energy traps in energy migration-based upconversion processes.

Long-read genome sequencing reveals the sequence characteristics of pear self-incompatibility locus.

The S-RNase-based self-incompatibility locus (S-locus) in Petunia species contains 16-20 F-box genes, which collaboratively function in the recognition and subsequent degradation of non-self S-RNases, while distinguishing them from self S-RNase. However, the number of S-locus F-box genes (SFBBs) physically interacted with non-self S-RNases remains uncertain in Pyrus species. Utilizing Pacbio long-read sequencing, we successfully assembled the genome of pear cultivar 'Yali' (Pyrus bretschneideri), and identified 19 SFBBs from the Pyrus S-locus spanning approximately 1.

Structurally diverse abietane diterpenoids from the whole plants of Salvia przewalskii Maxim. With anti-inflammatory activity.

Using bioactivity guidance, eight previously undescribed abietane diterpenoids (1-8), were isolated from the whole plants of Salvia przewalskii Maxim. along with seven known analogues (9-15). Their structures were elucidated by extensive spectroscopic analyses, quantum chemical calculations, and single crystal X-ray diffraction.

Computational Elucidation of a Monobody Targeting the Phosphatase Domain of SHP2.

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) is a key regulator in cellular signaling pathways because its dysregulation has been implicated in various pathological conditions, including cancers and developmental disorders. Despite its importance, the molecular basis of SHP2's regulatory mechanism remains poorly understood, hindering the development of effective targeted therapies. In this study, we utilized the high-specificity monobody Mb11 to investigate its interaction with the SHP2 phosphatase domain (PTP) using multiple replica molecular dynamics simulations.

Organelle-like structural evolution of coacervate droplets induced by photopolymerization.

The dynamic study of coacervates in vitro contributes our understanding of phase separation mechanisms in cells due to complex intracellular physiology. However, current researches mainly involve the use of exogenous auxiliary agents to form multi-compartmental coacervates with short-term stability. Herein, we report the endogenous self-organizing of multi-component coacervates (HA/PDDA/BSA/DMAEMA) induced by a dynamic stimulation process of protein-mediated photopolymerization.

Abnormal Expression of Peripheral Blood Leukocyte Surface Markers in Retinopathy of Prematurity Patients.

Objective: Our study compares immune cell profiles in preterm infants with and without severe ROP, identifying risk factors for its development to explore both immunological aspects and determinants of ROP in preterm infants.

Methods: Infants born between January 2023 to December 2023 at the Children's Hospital of Shanxi were enrolled in this study according to the inclusion criteria. Patients were divided into a test group or a control group based on the need for Type 1 ROP treatment.

Novel Indoleamine-2,3-Dioxygenase-Targeted Pt(IV) Prodrugs Regulate the Tumor Immune Microenvironment to Achieve Chemoimmunotherapy and .

Convincing evidence revealed that some platinum-based drugs could stimulate immunological recognition, thereby inducing immunogenic cell death (ICD). Indoleamine-2,3-dioxygenase (IDO) is overexpressed in tumors, which caused exhaustion of tryptophan (T-cell energy) and constructed an immunosuppressive tumor microenvironment. Herein, considering IDO inhibition to improve chemotherapy, a series of IDOi-Pt(IV) prodrugs were designed to not only target DNA and IDO but also facilitate tumor-antigen exposure and immunomodulation.

UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy.

Background: Advanced triple-negative breast cancer (TNBC) is prone to brain metastasis (BrM). The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it is vital to comprehend the molecular mechanism behind it.

Methods: The protein chip analysis was conducted to identify any abnormal UBE2T protein expression in TNBC, especially BrM.

Exploring Endothelial Cell Dysfunction's Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications.

The intricate linking between the health of blood vessels and the functioning of neurons has attracted growing attention in the context of disorders that affect the neurological environment. Endothelial cells, forming the blood-brain barrier and blood-retinal barrier, play a fundamental role in maintaining the integrity of the brain-retina microenvironment connection. This review explores the molecular foundations of endothelial cell dysfunction and its implications for the brain-retina interaction.

Self-assembled HO-1i-Pt(IV) nanomedicine targeting p38/MAPK and MDR pathways for cancer chemo-immunotherapy.

Platinum(II)-based antitumor drugs are widely used in clinics but limited by severe side effects and resistance. Multi-target Platinum(IV) complexes are emerging as ideal alternatives. Heme oxygenase-1 (HO-1) works as a rate-limiting step in heme degradation and is overexpressed in malignant tumors.

Epidemiological Characteristics of Sporadic Foodborne Diseases Caused by - China, 2013-2022.

Introduction: () is a common foodborne pathogen in coastal areas of China. Most epidemiological studies on have focused on foodborne disease outbreaks, with fewer studies based on long-term, continuous, and systematic sentinel surveillance.

Methods: Data were collected from the national foodborne disease active surveillance program in 31 provincial-level administrative divisions (PLADs) in China from 2013 to 2022.

Observing non-Hermiticity induced chirality breaking in a synthetic Hall ladder.

Non-Hermitian topological photonics plays a key role in bridging topological matter with gain and loss engineering in optics. Here we report the experimental observation of the break of chiral currents in a Hall ladder from the non-Hermiticity by constructing synthetic frequency dimension in two rings, where currents on both legs of the ladder co-propagate in the same direction. The origin of such phenomena is resulted from the interplay between the effective magnetic flux and the on-site gain and loss.

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery.

G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors and are highly effective targets for therapeutic drugs. GPCRs couple different downstream effectors, including G proteins (such as Gi/o, Gs, G12, and Gq) and β-arrestins (such as β-arrestin 1 and β-arrestin 2) to mediate diverse cellular and physiological responses. Biased signaling allows for the specific activation of certain pathways from the full range of receptors' signaling capabilities.

Characterization and Implications of the Regionally Prevalent ST8333 Strains of Serotype 4,[5],12:i: - China, 2017-2023.

What Is Already Known About This Topic?: is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year. The increasing prevalence of the ST34 serotype 4,5,12:i:-(. 4,[5],12:i:-) poses a substantial public health threat in China.

Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B.

Background: Dysregulated and excessive inflammatory reactions can lead to tissue damage, which is the underlying cause of most human diseases. Menisoxoisoaporphine A (MA), a novel oxoisoaporphine alkaloid, was obtained from Menispermi Rhizoma, a traditional Chinese medicinal herb used in the treatment of inflammatory conditions in clinical practice. This suggests that MA has very promising potential for the development of anti-inflammatory therapeutics.

Internet of Things-Based Automated Solutions Utilizing Machine Learning for Smart and Real-Time Irrigation Management: A Review.

This systematic review critically evaluates the current state and future potential of real-time, end-to-end smart, and automated irrigation management systems, focusing on integrating the Internet of Things (IoTs) and machine learning technologies for enhanced agricultural water use efficiency and crop productivity. In this review, the automation of each component is examined in the irrigation management pipeline from data collection to application while analyzing its effectiveness, efficiency, and integration with various precision agriculture technologies. It also investigates the role of the interoperability, standardization, and cybersecurity of IoT-based automated solutions for irrigation applications.

Complement C1q is a key player in tumor-associated macrophage-mediated CD8 T cell and NK cell dysfunction in malignant pleural effusion.

Macrophages play a crucial role in malignant pleural effusion (MPE), a frequent complication of advanced cancer. While C1q macrophages have been identified as a pro-tumoral cluster, direct evidence supporting the role of C1q-mediated macrophages remains to be elucidated. This study employed global and macrophage-specific knockout mice to investigate the role of C1q in MPE.

Design and synthesis of FeS/graphite sandwich structure with enhanced lithium-storage performance for lithium-ion and solid-state lithium batteries.

As a conversion-type cathode material, FeS emerges as a promising candidate for the next generation of energy storage solutions, attributed to its cost-effectiveness, environment-friendliness and high theoretical capacity. However, several challenges hinder its practical application, including sluggish kinetics, insulating reaction products and significant volume fluctuation during cycling, which collectively compromise its rate capability and cycle stability. Herein, a well-designed sandwich structure of FeS embedded between graphite layers (FeS/C) is obtained using a chloride intercalation and sulfidation strategy.

Efficient Organic Light-Emitting Diodes Obtained by Introducing Gadolinium (Gd) Complexes Based on Pyrazolone Derivative Ligands as Hole Trappers.

The utilization of lanthanide (Ln) complexes in the realm of organic light-emitting diodes (OLEDs) has garnered extensive interest, particularly in their role as luminescent materials or electron trappers. A series of gadolinium (Gd) complexes with energy levels of high HOMO/LUMO and different triplet state energies were designed and synthesized by introducing substituents with different electronic effects onto the pyrazolone derivative ligands. Subsequently, these complexes were precisely purified by vacuum sublimation and codoped into the light-emitting layer (EML) of the OLEDs.

Compact silicon photonic-lantern mode (de)multiplexer based on tilt slot waveguide.

As the key component in on-chip mode-division multiplexing systems, a compact silicon photonic-lantern mode (de)multiplexer is proposed and demonstrated using the shallow-etched tilt slot waveguide. The proposed six-mode (de)multiplexer is designed as a constant coupling length of 11.7 µm for each mode conversion and eliminates the adiabatic transition tapers for cascaded asymmetric directional couplers, which have an ultra-short total length of 69 µm.

A highly branched glucomannan from the fruiting body of Schizophyllum commune: Structural characteristics and antitumor properties analysis.

In this study, a highly branched glucomannan (SCP-1) from Schizophyllum commune fruiting body with good solubility was isolated, and its structural characteristics and antitumor properties were analyzed. The monosaccharides of SCP-1 were fucose, glucosamine hydrochloride, galactose, glucose and mannose with a relative molar ratio of 14:6:210:593:177, and the molecular weight (Mw) of SCP-1 was 15.1 kDa.

Efficient tetracycline degradation using carbon quantum dot modified TiO@LaFeO hollow core shell photocatalysts.

Efficient harnessing of solar energy presents a significant challenge in environmental cleanup efforts. This study develops a highly effective carbon quantum dots-modified hollow core-shell TiO-LaFeO heterojunction photocatalyst (CDs-TLFO). Structural analysis confirmed that nanosheets are loaded with CQDs, forming a hollow core-shell structure with intimate interconnection.