Investigation on the reactive transport characteristic of uranium-bearing sandstone during the in-situ leaching mining uranium.

The multi-phase flow in dynamic pore-fracture is crucial to the safety and efficient uranium mining using the in-situ leaching method. In this study, the pore-fracture evolution and multi-phase flow morphology was investigated using the online low-field nuclear magnetic resonance (NMR) system, and the relationship of pore structure, permeability transformation and chemical reaction was analyzed. The results show that the adsorption pore (0.

Mid-urethral sling with proper sling tension is an effective treatment for stress urinary incontinence in women after pelvic radiotherapy: a pilot study of case series.

Background: At present, consensus on the management of female stress urinary incontinence (SUI) after pelvic radiotherapy is lacking. We aim to assess the clinical effects of mid-urethral sling (MUS) for the treatment of SUI after pelvic radiotherapy in women.

Methods: We conducted a retrospective review of the clinical database of female with SUI after pelvic radiotherapy from June 2015 to February 2022.

Brassinosteroid Enhances Cucumber Stress Tolerance to NaHCO by Modulating Nitrogen Metabolism, Ionic Balance and Phytohormonal Response.

Under NaHCO stress, exogenous 24-epibrassinolide (EBR) markedly alleviated Na accumulation in cucumber plants, thereby decreasing the Na/K, Na/Mg, and Na/Ca ratios. This mitigation was accompanied by elevated concentrations of K, Ca, and Mg, as well as enhanced expression of the and genes. In addition, the activities of plasma membrane H-ATPase, vesicular membrane H-ATPase, and vesicular membrane H-PPase were significantly increased, contributing to the maintenance of ionic balance in cucumber plants.

Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence.

Gut microbiota plays a crucial role in the host health in the aging process. However, the mechanisms for how gut microbiota triggers cellular senescence and the consequent impact on human aging remain enigmatic. Here we show that phenylacetylglutamine (PAGln), a metabolite linked to gut microbiota, drives host cellular senescence.

Research on Deep Learning Detection Model for Pedestrian Objects in Complex Scenes Based on Improved YOLOv7.

Objective: Pedestrian detection is very important for the environment perception and safety action of intelligent robots and autonomous driving, and is the key to ensuring the safe action of intelligent robots and auto assisted driving.

Methods: In response to the characteristics of pedestrian objects occupying a small image area, diverse poses, complex scenes and severe occlusion, this paper proposes an improved pedestrian object detection method based on the YOLOv7 model, which adopts the Convolutional Block Attention Module (CBAM) attention mechanism and Deformable ConvNets v2 (DCNv2) in the two Efficient Layer Aggregation Network (ELAN) modules of the backbone feature extraction network. In addition, the detection head is replaced with a Dynamic Head (DyHead) detector head with an attention mechanism; unnecessary background information around the pedestrian object is also effectively excluded, making the model learn more concentrated feature representations.

Degradation of Rhodamine B by Visible Light Driven MoO@TiO Core-Shell Photocatalyst.

In this study, a MoO@TiO composite core-shell material was developed to remove Rhodamine B (RhB) dye through synergistic adsorption and photocatalytic degradation. n-n heterostructures were formed by coupling n-type semiconductors to enhance the efficiency of photocarrier separation and photocatalytic performance. MoO, which possesses strong adsorption capacity, was primarily used as a dye adsorbent.

Mixed-level designs with orthogonality and relatively optimal run order.

Orthogonality and optimality of run order are two important and worthy to be considered criteria in design of experiment. For the mixed-level designs commonly used in the case of unequal levels of factors in the experiment, both orthogonality and optimality of run order are taken into account at the same time in this paper. The construction methods of mixed-level designs with orthogonality and relatively minimum or maximum level changes are respectively proposed.

Preparation and Luminescence Properties of Broadband Orange-Emitting Persistent ScBaZnGaO:Bi Phosphor.

This article describes a new kind of afterglow material, ScBaZnGaO:Bi, which was synthesized through a high-temperature solid-phase method. Its crystal structure, photoluminescent characteristics, and afterglow characteristics were studied and analyzed. Upon excitation at 344 nm, ScBaZnGaO:Bi exhibits broadband emission with a central wavelength located at 571 nm (fwhm = 172.

SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.

Smoking is a well-established risk factor for several oral diseases, including oral cancer, oral leukoplakia and periodontitis, primarily related to reactive oxygen species (ROS). SS-31, a mitochondria-targeting tetrapeptide, has exhibited demonstrable efficacy in medical conditions by attenuating mitochondrial ROS production. However, its potential in the treatment of oral diseases remains underexplored.

[Medium to long-term efficacy of tension-free vaginal tape procedure in the treatment of female recurrent stress urinary incontinence].

Objective: To investigate the effectiveness and clinical efficacy of tension-free vaginal tape (TVT) surgery in treating female recurrent stress urinary incontinence (rSUI).

Methods: A retrospective analysis was conducted on 24 patients who experienced recurrence of mid-urethral sling failure and were treated with TVT surgery at Beijing Chao-Yang Hospital from January 2016 to June 2020. Basic patient information was collected.

The impact of gender differences on the clinical characteristics of critically ill patients with venous thromboembolism: A retrospective, observational study.

The aim of this study is to describe the general information, disease and treatment of venous thromboembolism (VTE) in critically ill patients, to explore the characteristics of severe patients with deep venous VTE and provide clinical reference data for the prevention and treatment of VTE in critically ill patients. This study carried out a retrospective study on the medical records of patients who were treated in the intensive care unit of Affiliated Hospital of Jining Medical College from 2020 to 2022. The general data, general conditions, drug use, past history, VTE prevention measures, post-VTE conditions, and Padua risk score of 297 patients with VTE during the period of hospitalization in intensive care unit (ICU) were classified and statistically analyzed.

A novel inhalable nanobody targeting IL-4Rα for the treatment of asthma.

Background: Inhalable biologics represent a promising approach to improve the efficacy and safety of asthma treatment. Although several mAbs targeting IL-4 receptor α chain (IL-4Rα) have been approved or are undergoing clinical trials, the development of inhalable mAbs targeting IL-4Rα presents significant challenges.

Objective: Capitalizing on the distinctive advantages of nanobodies (Nbs) in maintaining efficacy during storage and administration, we sought to develop a novel inhalable IL-4Rα Nb for effectively treating asthma.

Efficacy of Mid-Urethral Sling and Urethral Dilation for Stress Urinary Incontinence Combined with Urethral Stricture in Women.

Objective: To investigate the potential clinical benefits of mid-urethral sling (MUS) and urethral dilatation (UD) operations for the treatment of stress urinary incontinence (SUI) combined with urethral stricture.

Study Design: Descriptive study. Place and Duration of the Study: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, from January 2017 to 2022.

Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy.

Purpose: To examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregnancy.

Materials And Methods: A prospective cohort of 80 PCOS women who expressed the desire for fertility was enrolled in this study. All of them received the ovulation induction by using letrozole.

MR defecography in assessing stress urinary incontinence with or without symptomatic pelvic organ prolapse.

Purpose: Utilize magnetic resonance defecography (MRD) to analyze the primary pelvic floor dysfunctions in patients with stress urinary incontinence (SUI) associated with pelvic organ prolapse (POP), and in SUI patients with asymptomatic POP.

Method: We performed MRD in both SUI and POP subjects. As a primary analysis, the functional MR parameters were compared between the isolated POP and POP combined SUI groups.

Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention.

Purpose: Periodontitis-associated bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are closely linked to the risk of oral squamous cell carcinoma (OSCC). Emerging studies have indicated that another common periodontal pathogen, Prevotella intermedia (P. intermedia), is enriched in OSCC and could affect the occurrence and progression of OSCC.

Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment.

Background: Oral microbial dysbiosis contributes to the development of oral squamous cell carcinoma (OSCC). Our previous study showed that Prevotella intermedia (P. intermedia) were enriched in the oral mucosal surface, plaque, and saliva of patients with OSCC.

Validation of the 9th edition of the TNM staging system for non-small cell lung cancer with lobectomy in stage IA-IIIA.

Objectives: The 9th edition of tumour-node-metastasis (TNM) staging for lung cancer was announced by Prof Hisao Asamura at the 2023 World Conference on Lung Cancer in Singapore. The purpose of this study was to externally validate and compare the latest staging of lung cancer.

Methods: We collected 19 193 patients with stage IA-IIIA non-small cell lung cancer (NSCLC) who underwent lobectomy from the Surveillance, Epidemiology and End Results database.

High performance production process development and scale-up of an anti-TSLP nanobody.

Nanobodies (Nbs) represent a class of single-domain antibodies with great potential application value across diverse biotechnology fields, including therapy and diagnostics. Thymic Stromal Lymphopoietin (TSLP) is an epithelial cell-derived cytokine, playing a crucial role in the regulation of type 2 immune responses at barrier surfaces such as skin and the respiratory/gastrointestinal tract. In this study, a method for the expression and purification of anti-TSLP nanobody (Nb3341) was established at 7 L scale and subsequently scaled up to 100 L scale.

The Effects of Exogenous 2,4-Epibrassinolide on the Germination of Cucumber Seeds under NaHCO Stress.

This investigation focused on the suppressive impact of varying NaHCO concentrations on cucumber seed germination and the ameliorative effects of 2,4-Epibrassinolide (EBR). The findings revealed a negative correlation between NaHCO concentration and cucumber seed germination, with increased NaHCO concentrations leading to a notable decline in germination. Crucially, the application of exogenous EBR significantly counteracted this inhibition, effectively enhancing germination rates and seed vigor.

Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies.

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment. Within this landscape, the innate immune system, a critical sentinel protecting against tumor incursion, is a key player. The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway has been found to be a linchpin of innate immunity: activation of this signaling pathway orchestrates the production of type I interferon (IFN-α/β), thus fostering the maturation, differentiation, and mobilization of immune effectors in the tumor microenvironment.