Clisp: A Robust Interactive Segmentation Framework for Pathological Images.

Recently, automatic segmentation algorithms based on deep learning have achieved promising results on various pathological image segmentation tasks. However, the inherent data-hungry nature of these methods and the high cost of annotating pathological images make them difficult to apply to practical clinical tasks. To address this problem, many studies have explored interactive segmentation methods to reduce the cost of annotating pathological images, which replace pixel-by-pixel annotation operations with clicks or other user instructions.

Orientation-Dependent Oxygen Evolution Catalytic Performance and Mechanistic Insights of Epitaxial CoS Thin Films.

Cobalt sulfide (CoS) nanomaterials exhibit an efficient electrochemical catalytic performance due to their unique properties and electronic structure. The preparation of epitaxial CoS thin films with varying crystal orientations and the study of their catalytic kinetics and mechanisms remain significant gaps. This study addresses the preparation of epitaxial CoS thin films with orientations of (100), (110), and (111) on yttrium-doped zirconia (YSZ) substrates using pulsed laser deposition.

GCSTG: Generating Class-confusion-aware Samples with a Tree-structure Graph for Few-shot Object Detection.

Few-Shot Object Detection (FSOD) aims to detect the objects of novel classes using only a few manually annotated samples. With the few novel class samples, learning the inter-class relationships among foreground and constructing the corresponding class hierarchy in FSOD is a challenging task. The poor construction of the class hierarchy will result in the inter-class confusion problem, which has been identified as a primary cause of inferior performance in novel classes by recent FSOD methods.

Exogenous application of luteolin enhances wheat resistance to Puccinia striiformis f. sp. tritici.

The accumulation of flavonoids facilitates plant resistance to biotic stress. However, few studies have explored the functions of flavonoids during the interaction between wheat and Puccinia striiformis Westendorp f. sp.

Crystalline Structural Engineering of an Electrical Insulator Into A Highly-Active Electrocatalyst for Oxygen Evolution.

The development of highly efficient electrocatalysts for oxygen evolution reaction (OER) is crucial for water splitting. Due to flexible lattice structure and tunable electronic properties, perovskite oxides are considered promising candidates for oxygen evolution catalysts. In this work, pulsed laser deposition (PLD) is employed to fabricate well-defined amorphous SrRuO (SRO) films (insulator) on a glassy carbon (GC) substrate as the OER catalyst, demonstrating superior OER catalytic activity compare with crystalline SRO.

Spatially targeted triple amplification of oxidative stress for enhanced tumor therapy via effective modulation of metal ion valence states.

Inducing oxidative stress through metal ions activated biocatalysis is a fundamental mechanism of metal ion-interference therapy (MIIT). However, the actual catalytic efficiency of MIIT is often limited by the random valence states of metal ions and scattered space. Herein, copper-iron bimetallic sulfide nanoparticles coated with bovine serum albumin (CFS NPs) are synthesized through metal ion valence modulation strategy.

Puccinia striiformis Effector PNPi Suppresses TaIAA14 Expression to Inhibit Host Cell Death Response.

Fungal pathogens secrete effectors that suppress the hypersensitive response (HR) of the host, characterised by programmed cell death, facilitating colonisation. However, how effectors manipulate host cell death remains poorly understood. In this study, we discovered that the Puccinia striiformis effector PNPi (Puccinia NPR1 interactor) suppressed BAX-induced cell death in Nicotiana benthamiana.

Increased versatility and convenience: Advances and strategy optimization of Receptor-Mediated Ovary Transduction of Cargo-mediated genetic modification in insects.

Genetic modification via gene editing has become a widely adopted and demonstrably effective method in functional gene research within entomology. However, the optimal efficiency and simplicity of delivering exogenous guide RNA-clustered regularly interspaced short palindromic repeats-associated protein 9 complexes into target tissues are crucial for successful gene editing. The Receptor-Mediated Ovary Transduction of Cargo (ReMOT) strategy, which simplifies the delivery process, target-site selection, technical requirements, and delivery cost compared with embryonic microinjection, enabling efficient editing at the germline level, is gaining increasing attention.

[Analysis of correlation between Barthel index score and preoperative occurrence of deep vein thrombosis in patients undergoing total hip arthroplasty revision surgery].

Objective: To explore the correlation between the Barthel index score and other factors with the preoperative occurrence of deep vein thrombosis (DVT) in patients undergoing total hip arthroplasty (THA) revision surgery.

Methods: A retrospective analysis was conducted on clinical data from 122 patients who met the inclusion criteria and underwent THA revision surgery between April 2017 and November 2020. Among them, 61 were male and 61 were female, with an age range of 32-85 years (mean, 65.

CircMFN2/miR-361-3p/ELK1 feedback loop promotes glutaminolysis and the progression of hepatocellular carcinoma.

Current evidence indicates that circRNAs are involved in the development of multiple malignancies including hepatocellular carcinoma (HCC). However, the specific functions of circRNAs in HCC metabolism and progression and their underlying regulatory mechanisms remain unclear. We have identified a novel circRNA circMFN2, by bioinformatics analysis of circRNA microarray data from the GEO database.

Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia.

Background: The homeobox (HOX) genes especially for HOXA cluster play crucial roles in leukemogenesis. HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML.

Transition Metal Carbonitride MXenes Anchored with Pt Sub-Nanometer Clusters to Achieve High-Performance Hydrogen Evolution Reaction at All pH Range.

Transition metal carbides, known as MXenes, particularly TiCT, have been extensively explored as promising materials for electrochemical reactions. However, transition metal carbonitride MXenes with high nitrogen content for electrochemical reactions are rarely reported. In this work, transition metal carbonitride MXenes incorporated with Pt-based electrocatalysts, ranging from single atoms to sub-nanometer dimensions, are explored for hydrogen evolution reaction (HER).

Fabricating Lattice-Confined Pt Single Atoms With High Electron-Deficient State for Alkali Hydrogen Evolution Under Industrial-Current Density.

The confining effect is essential to regulate the activity and stability of single-atom catalysts (SACs), but the universal fabrication of confined SACs is still a great challenge. Here, various lattice-confined Pt SACs supported by different carriers are constructed by a universal co-reduction approach. Notably, Pt single atoms confined in the lattice of Ni(OH) (Pt/Ni(OH)) with a high electron-deficient state exhibit excellent activity for basic hydrogen evolution reaction (HER).

Left Insula and Right Middle Temporal Gyrus Dominate Cortical Network Discriminating Arousal-dependent Emotions.

Emotion processing is an integral part of everyone's life. The basic neural circuits involved in emotion perception are becoming clear, though the emotion's cognitive processing remains under investigation. Utilizing the stereo-electroencephalograph with high temporal-spatial resolution, this study aims to decipher the neural pathway responsible for discriminating low-arousal and high-arousal emotions.

Quantitative Site-Specific Glycoproteomics Reveals Glyco-Signatures for Breast Cancer Diagnosis.

Intact glycopeptide characterization by mass spectrometry has proven to be a versatile tool for site-specific glycoproteomics analysis and biomarker screening. Here, we present a method using a new model of a Q-TOF instrument equipped with a Zeno trap for intact glycopeptide identification and demonstrate its ability to analyze large-cohort glycoproteomes. From 124 clinical serum samples of breast cancer, noncancerous diseases, and nondisease controls, a total of 6901 unique site-specific glycans on 807 glycosites of proteins were detected.

Elucidating the molecular association and potential mechanisms between psoriasis and atrial fibrillation through biomarker and immune infiltration analysis.

Multiple studies have suggested that psoriasis may increase the risk of atrial fibrillation (AF). However, the molecular and immune mechanisms underlying this association remain unclear. This study initially downloaded gene expression profiles for psoriasis and AF from the Gene Expression Omnibus database.

DSiam-CnK: A CBAM- and KCF-Enabled Deep Siamese Region Proposal Network for Human Tracking in Dynamic and Occluded Scenes.

Despite the accuracy and robustness attained in the field of object tracking, algorithms based on Siamese neural networks often over-rely on information from the initial frame, neglecting necessary updates to the template; furthermore, in prolonged tracking situations, such methodologies encounter challenges in efficiently addressing issues such as complete occlusion or instances where the target exits the frame. To tackle these issues, this study enhances the SiamRPN algorithm by integrating the convolutional block attention module (CBAM), which enhances spatial channel attention. Additionally, it integrates the kernelized correlation filters (KCFs) for enhanced feature template representation.

Safety and clinical efficacy of modified tracer fixation technique in orthopedic robot-assisted percutaneous vertebroplasty for Kümmell's disease.

The rising incidence of osteoporotic vertebral compression fractures (OVCF) has increased the demand for precise treatments like robot-assisted percutaneous vertebroplasty (PVP), especially for conditions like Kümmell's disease that require high surgical accuracy. However, the traditional tracer fixation method has certain limitations. This study aimed to compare the safety and clinical efficacy of a modified tracer fixation technique with the traditional fixation method in robot-assisted percutaneous vertebroplasty (PVP) for Kümmell's disease.

Tantalum-stabilized ruthenium oxide electrocatalysts for industrial water electrolysis.

The iridium oxide (IrO) catalyst for the oxygen evolution reaction used industrially (in proton exchange membrane water electrolyzers) is scarce and costly. Although ruthenium oxide (RuO) is a promising alternative, its poor stability has hindered practical application. We used well-defined extended surface models to identify that RuO undergoes structure-dependent corrosion that causes Ru dissolution.

Chromosome-scale assembly and annotation of the wild wheat relative Aegilops comosa.

Wild relatives of wheat are valuable sources for enhancing the genetic diversity of common wheat. Aegilops comosa, an annual diploid species with an MM genome constitution, possesses numerous agronomically valuable traits that can be exploited for wheat improvement. In this study, we report a chromosome-level genome assembly of Ae.

Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer.

Constitutive androstane receptor (CAR) is a xenosensor that is almost exclusively expressed in the liver. Studies in rodents suggest an oncogenic role for CAR in liver cancer, but its role in human liver cancer is unclear. We aimed to investigate the functional roles of CAR in human liver cancer with a focus on the liver cancer stem cells.

An Orientation-Enhanced Interlayer Enables Efficient Sn-Pb Binary Perovskite Solar Cells and All-Perovskite Tandem Solar Cells with High Fill Factors.

The performance of narrow-bandgap (NBG) perovskite solar cells (PSCs) is limited by the severe nonradiative recombination and carrier transport barrier at the electron selective interface. Here, we reveal the importance of the molecular orientation for effective defect passivation and protection for Sn at the perovskite/C interface. We constructed an internally self-anchored dual-passivation (ISADP) layer, where the orientation of PCBM can be significantly enhanced by the interaction between ammonium and carbonyl groups.