Harnessing ROS Amplification and GSH Depletion Using a Carrier-Free Nanodrug to Enhance Ferroptosis-Based Cancer Therapy.

Ferroptosis, a non-apoptotic form of cell death characterized by the production of reactive oxygen species (ROS) and massive accumulation of lipid peroxidation (LPO), shows significant promise in cancer therapy. However, the overexpression of glutathione (GSH) at the tumor site and insufficient ROS often result in unsatisfactory therapeutic efficacy. A multistage, GSH-consuming, and ROS-providing carrier-free nanodrug capable of efficiently loading copper ions (Cu), sorafenib (SRF), and chlorogenic acid (CGA) (Cu-CGA-SRF, CCS-NDs) is developed to mediate enhanced ferroptosis therapy.

Micro-nano bubble ozonation for effective treatment of ibuprofen-laden wastewater and enhanced anaerobic digestion performance.

The pharmaceutical industry plays a crucial role in driving global economic growth but also poses substantial environmental challenges, particularly in the efficient treatment of production wastewater. This study investigates the efficacy of micro-nano bubble (MNB) ozonation for treating high-strength ibuprofen (IBU)-laden wastewater (49.9 ± 2.

Microstructure and Hardness of Nickel-Based Coatings Prepared by Laser Additive Manufacturing on Water-Cooled Substrate: An Experimental and Numerical Study.

The excess heat generated during the laser additive manufacturing process is prone to cause coating defects; a water-cooled substrate can effectively remove the excess heat and improve the hardness of the coating. In this study, the effects of water-cooled substrate on the microstructure and hardness of laser additive manufactured nickel-based coatings were investigated by experimental and numerical simulations. The results showed that the water-cooled substrate decreased the size of columnar crystals and increased the number as well as the length of secondary dendrite crystals at the bottom of the nickel-based coatings.

A novel platelets-related gene signature for predicting prognosis, immune features and drug sensitivity in gastric cancer.

Background: Platelets can dynamically regulate tumor development and progression. Nevertheless, research on the predictive value and specific roles of platelets in gastric cancer (GC) is limited. This research aims to establish a predictive platelets-related gene signature in GC with prognostic and therapeutic implications.

Corrigendum: Integrated analysis of single-cell and bulk RNA sequencing data reveals a cellular senescence-related signature in hepatocellular carcinoma.

[This corrects the article DOI: 10.3389/fcell.2024.

Inhibitory effects of circR-127aa on gastric cancer progression and tumor growth.

This study investigates the function of a newly identified 127-amino acid peptide, circR-127aa, encoded by hsa_circ_0075402 (circRACK1), in gastric cancer (GC), a condition with significant prevalence in China. Utilizing a comprehensive analysis of circular RNA (circRNA) ribosome profiling data alongside experimental validations through mass spectrometry, Western blot, and immunofluorescence, we demonstrate that circR-127aa Inhibits Malignant Phenotypes and suppresses tumor growth in nude mice models. Significantly, the interaction of circR-127aa with Vimentin, a crucial element in actin-actin-cytoskeletal remodeling, indicates that circR-127aa functions as a tumor suppressor by facilitating the ubiquitination of Vimentin.

Home physical therapy versus telerehabilitation in improving motor function and quality of life in Parkinson's disease: a randomized controlled trial.

Background: Over the past few years, the development of telerehabilitation has advanced rapidly. Patients with Parkinson's disease (PwPD) often have difficulty with mobility, making it challenging for them to perform centre-based exercise.This study aims to compare the effectiveness and adherence of home physical therapy (HPT) and telerehabilitation (TR) in mitigating motor symptoms and improving the quality of life in patients with mild to moderate Parkinson's disease.

Antidiabetic and Antigout Properties of the Ultrasound-Assisted Extraction of Total Biflavonoids from Revealed by In Vitro and In Silico Studies.

In this study, the extraction, purification and metabolic enzyme inhibition potential of were investigated. In order to extract the total biflavonoids from (SDTBs), the optimum extraction process was obtained by optimizing the ultrasonic extraction parameters using response-surface methodology. This resulted in a total biflavonoid content of 22.

Integrated Review of Transcriptomic and Proteomic Studies to Understand Molecular Mechanisms of Rice's Response to Environmental Stresses.

Rice ( L.) is grown nearly worldwide and is a staple food for more than half of the world's population. With the rise in extreme weather and climate events, there is an urgent need to decode the complex mechanisms of rice's response to environmental stress and to breed high-yield, high-quality and stress-resistant varieties.

Highly Porous Co-Al Intermetallic Created by Thermal Explosion Using NaCl as a Space Retainer.

Co-Al porous materials were fabricated by thermal explosion (TE) reactions from Co and Al powders in a 1:1 ratio using NaCl as a space retainer. The effects of the NaCl content on the temperature profiles, phase structure, volume change, density, pore distribution and antioxidation behavior were investigated. The results showed that the sintered product of Co and Al powders was solely Co-Al intermetallic, while the final product was CoAl with an abundant Co phase and minor CoAl and Co-Al phases after added NaCl dissolved out, due to the high T and low T.

Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria.

Current research reports that lactate affects Treg metabolism, although the precise mechanism has only been partially elucidated. In this study, we presented evidence demonstrating that elevated lactate levels enhanced cell proliferation, suppressive capabilities, and oxidative phosphorylation (OXPHOS) in human Tregs. The expression levels of Monocarboxylate Transporters 1/2/4 (MCT1/2/4) regulate intracellular lactate concentration, thereby influencing the varying responses observed in naive Tregs and memory Tregs.

Non-fluorinated lignin-based melamine sponges with superhydrophobic and photothermal properties for multi-functional applications.

Frequent oil spills and the discharge of oily wastewaters become a significant threat to the environment and ecosystem. Herein, a non-fluorinated lignin-based melamine sponge with superhydrophobic and photothermal properties (labeled as MS@COF/LPs/PDMS) has been achieved by decorating with covalent organic framework (COF), lignin particles (LPs) and PDMS. The MS@COF/LPs/PDMS shows excellent surface superhydrophobicity with a water contact angle of 152.

Prophylactic supplementation with selenium nanoparticles protects against foodborne toxin zearalenone-induced intestinal barrier dysfunction.

Selenium nanoparticles (SeNPs) have been used as a potential alternative to other forms of selenium in nutritional supplements for the treatment and prevention of inflammatory and oxidative stress-related diseases. Zearalenone (ZEA) is a foodborne mycotoxin present in grains that poses a health threat. Here, we investigated the adverse impacts of ZEA on intestinal homeostasis and explored the protective effects of probiotic-synthesized SeNPs against its damage.

Inhalable mucin-permeable nanomicelles deliver antibiotics for effective treatment of chronic pneumonia.

() pneumonia can have serious physiological consequences, particularly when biofilms are formed. Although inhaled therapy is preferred, inhaled drugs tend to get trapped by pulmonary mucus, which hinders efficient antibiotic permeability through mucus and biofilms. In this study, we prepare poly[2-(pentamethyleneimino)ethyl methacrylate]--poly[2-(-oxide-pentamethyleneimino)ethyl methacrylate] (PPEMA--PPOEMA) micelles loaded with azithromycin (AZM) using reversible addition-fragmentation chain transfer (RAFT) polymerization to achieve effective treatment of pneumonia.

Predicting flood stages in watersheds with different scales using hourly rainfall dataset: A high-volume rainfall features empowered machine learning approach.

Accurate prediction of instantaneous high lake water levels and flood flows (flood stages) from micro-catchments to big river basins are critical for flood forecasting. Lake Carl Blackwell, a small-watershed reservoir in the south-central USA, served as a primary case study due to its rich historical dataset. Bearing knowledge that both current and previous rainfall contributes to the reservoirs' water body, a series of hourly rainfall features were created to maximize predicting power, which include total rainfall amounts in the current hour, the past 2 h, 3 h, …, 600 h in addition to previous-day lake levels.

Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis.

Retinal detachment (RD) is a sight-threatening condition that occurs in several retinal diseases. Microglia that reside in retina are activated after RD and play a role in the death of photoreceptor cells. The involvement of microglial pyroptosis in the early pathological process of RD is still unclear.

The Molecular Mechanism of Cold-Stress Tolerance: Cold Responsive Genes and Their Mechanisms in Rice ( L.).

Rice ( L.) production is highly susceptible to temperature fluctuations, which can significantly reduce plant growth and development at different developmental stages, resulting in a dramatic loss of grain yield. Over the past century, substantial efforts have been undertaken to investigate the physiological, biochemical, and molecular mechanisms of cold stress tolerance in rice.

Integrated analysis of single-cell and bulk RNA sequencing data reveals a cellular senescence-related signature in hepatocellular carcinoma.

The mortality of hepatocellular carcinoma (HCC) is on the rise globally, particularly in the Western world, with etiology gradually shifting from virus-related liver diseases to metabolic disorders such as non-alcoholic fatty liver disease. Early detection of HCC is challenging, and effective prognostic indicators are currently lacking, urgently necessitating reliable markers to assist in treatment planning and clinical management. Here, we introduce hepatocellular carcinoma senescence genes (HSG) to assess cellular senescence in HCC and devise a hepatocellular carcinoma senescence score (HSS) for prognostic prediction.

Characterization and the first complete genome sequence of a novel strain of Bergeyella porcorum isolated from pigs in China.

Background: Bergeyella porcorum is a newly identified bacterium that has an ambiguous relationship with pneumonia in pigs. However, few studies have adequately characterized this species.

Results: In this study, we analyzed the morphological, physiological, and genomic characteristics of the newly identified B.

The Consistency of Anti-Toxocara IgG Between the Aqueous Humor and Vitreous of Patients With Clinically Suspected Ocular Toxocariasis.

Purpose: To assess the consistencies of anti-Toxocara IgG (T-IgG) and Goldmann-Witmer coefficient (GWC) between paired aqueous humor (AH) and vitreous samples from patients with clinically suspected ocular toxocariasis (OT).

Design: Inter-test reliability assessment.

Methods: A total of 47 patients with clinically suspected OT who underwent vitrectomy were included.