Iodine intakes of pregnant females from Québec, Canada.

Background: Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 -2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.

Objectives: To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.

Friction Reduction and Antiwear Mechanisms of Cerium Sulfide Nanosheets under Different Sliding Conditions.

With the rapid development of modern industry, traditional lubricants often require a variety of additives to be used in conjunction with each other, which not only increases the cost but also causes a waste of resources. Therefore, the development of a lubricant additive with both a dyeing function and an antiwear and friction reduction performance can more effectively meet the industrial needs. Cerium sulfide (CeS), with its excellent photostability, weather resistance, thermal stability, and nontoxicity, shows great potential as an environmentally friendly pigment.

Cyclodextrin-based delivery systems for chemical and genetic drugs: Current status and future.

Cyclodextrins (CDs) are cyclic polysaccharides characterized by their unique hollow structure, making them highly effective carriers for pharmaceutical agents. CD-based delivery systems are extensively utilized to enhance drug stability, increase solubility, improve oral bioavailability, and facilitate controlled release and targeted delivery. This review initially provides a concise overview of nano drug delivery systems, followed by a detailed introduction of the structural features and benefits of CDs.

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from L.- Hand.-Mazz. herb pair.

Introduction: The L. (PVL) and Hand.-Mazz.

Hybrid entanglement carrying orbital angular momentum.

Hybrid continuous-variable (CV) and discrete-variable (DV) entanglement is an essential quantum resource of hybrid quantum information processing, which enables one to overcome the intrinsic limitations of CV and DV quantum protocols. Besides CV and DV quantum variables, introducing more degrees of freedom provides a feasible approach to increase the information carried by the entangled state. Among all the degrees of freedom of photons, orbital angular momentum (OAM) has potential applications in enhancing the communication capacity of quantum communication and precision of quantum measurement.

The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis.

Background: The body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.

Objective: This study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.

Methods: Literature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.

Nano-fibrous biopolymers as building blocks for gel networks: Interactions, characterization, and applications.

Biopolymers derived from natural resources are highly abundant, biodegradable, and biocompatible, making them promising candidates to replace non-renewable fossil fuels and mitigate environmental and health impacts. Nano-fibrous biopolymers possessing advantages of biopolymers entangle with each other through inter-/intra-molecular interactions, serving as ideal building blocks for gel construction. These biopolymer nanofibers often synergize with other nano-building blocks to enhance gels with desirable functions and eco-friendliness across various applications in biomedical, environmental, and energy sectors.

Endoscopic-Assisted Mandibular Angle Revision Using Patient-Specific PEEK Implants: Surgical Accuracy and Aesthetic Outcomes in Over-Resected Mandibles.

Background: Mandibular angle osteotomy (MAO) is a popular procedure to improve facial aesthetics, however, over-resection of the mandibular angle can lead to both functional and aesthetic challenges. Precision is essential in restoring these over-resected mandibles to achieve balanced outcomes. Polyetheretherketone (PEEK) implants offer biocompatibility, durability, and customization potential, making them valuable for achieving precise and predictable results.

NIR-II Fluorescence Imaging-guided Photothermal Activated Pyroptosis For Precision Therapy Of Glioma.

The resistance of cancer cells to apoptosis poses a significant challenge in cancer therapy, driving the exploration of alternative cell death pathways such as pyroptosis, known for its rapid and potent effects. While initial efforts focused on chemotherapy-induced pyroptosis, concerns about systemic inflammation highlight the need for precise activation strategies. Photothermal therapy emerges as a promising non-invasive technique, minimizing pyroptosis-related side effects by targeting tumors spatially and temporally.

Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner.

Abnormal tryptophan metabolism is closely linked with neurological disorders. Research has shown that indoleamine 2,3-dioxygenase 1 (IDO-1), the first rate-limiting enzyme in tryptophan degradation, is upregulated in Parkinson's disease (PD). However, the precise role of IDO-1 in PD pathogenesis remains elusive.

Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway.

Background: With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with the development of drug resistance. Aidi injection (ADI) is utilized in various cancers as a traditional Chinese medicine prescription. This study explores the molecular mechanism by which ADI, when combined with gefitinib, attenuates gefitinib resistance in PC9GR NSCLC cells.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

A H2S-activated NIR-II imaging probe for precise diagnosis and pathological evaluation of colorectal tumor.

The quick and accurate detection of colorectal cancer (CRC) is essential for improving the treatment efficacy and patient survival, which nevertheless remains challenging due to low specificity and sensitivity of current CRC diagnostic approaches. Therefore, providing a robust solution for real-time and accurate tumor delineation is highly desirable. We report a novel polyacrylic acid-mediated strategy to develop the endogenous hydrogen sulfide (HS)-activated NIR-II probe DCNP@PB for specific visualization of CRC and image-guided tumor surgery.

Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease.

Astrocyte-mediated neuroinflammation plays a key role in Parkinson's disease (PD) progression. The proinflammatory protein S100A9 is linked to various neurodegenerative diseases, but its involvement in astrocyte activation in PD remains unclear. Here, we investigate the role of S100A9 in astrocyte-mediated neuroinflammation in PD.

Investigation of a hemophilia family with one female hemophilia A patient and 12 male hemophilia A patients.

Hemophilia A (HA) is an X-chromosome-linked recessive genetic disorder. Female carriers may have bleeding symptoms, but rarely have moderate or severe disease. We identified a female patient with moderate HA by pedigree tracking and genetic testing in a HA family involving consanguineous marriage.

Popularizing Holistic High-Index Crystal Plane via Nonepitaxial Electrodeposition Toward Hydrogen-Embrittlement-Relieved Zn Anode.

Electrodeposition is promising to fabricate Zn electrodes affording nonepitaxial single-crystal textures. Previous research endeavors focus on achieving Zn(002) faceted deposition, nevertheless, the popularization of a high-index Zn plane with favorable electrochemical activity remains poorly explored. There also exists a deficiency in the assessment of the electrodeposited quality of Zn.

Effect of Baduanjin exercise on health and functional status in patients with chronic obstructive pulmonary disease: a community-based, cluster-randomized controlled trial.

Baduanjin has been shown to be an effective method of exercise for promoting body function in patients with chronic obstructive pulmonary disease (COPD). However, this method is rarely used by rural doctors in rural communities. The aim of this study was to compare the therapeutic effects of Baduanjin exercise with those of conventional pulmonary rehabilitation (CPR) implemented by rural doctors in patients with COPD.

Engineered Bacteria Manipulate Cysteine Metabolism to Boost Ferroptosis-Based Pancreatic Ductal Adenocarcinoma Therapy.

Cysteine metabolism is a key determinant of the defense against ferroptosis in pancreatic ductal adenocarcinoma (PDAC). Blocking cysteine metabolism may trigger potent ferroptosis in PDAC cells by generating lipid peroxides during tumor metabolic processes. However, current methods to limit cysteine availability fall short, failing to efficiently block cysteine metabolism due to inadequate tumor targeting and compensatory cysteine sources.

Effective Decolorization of Poly-γ-Glutamic Acid Fermentation Broth by Integrated Activated Carbon Adsorption and Isoelectric Point Precipitation of Glutamic Acid.

Poly-γ-glutamic acid (γ-PGA) is widely used in the field of biomedicine, food, agriculture, and ecological remediation. For the biosynthesis of γ-PGA, the pigments and remaining glutamate are two big problems that impede γ-PGA production by fermentation, and a trade-off between the decolorization rate and γ-PGA recovery rate during the purification process was found. The optimized static activated carbon adsorption conditions for treating the 2-times diluted cell-free supernatant (i.

Construction of Photothermal Intelligent Membranes for Point-of-Use Water Treatment.

For the removal of waterborne pathogens in remote areas and disaster emergency situations, point-source water treatment methods are more suitable. Photothermal sterilization is ideal for point-of-use (POU) systems, as it effectively eliminates pathogens without secondary pollution or bacterial resistance issues. By combining photothermal with membrane treatment, these membranes rapidly heat up under near-infrared (NIR) light, enabling both bacterial retention and sterilization.

Effect of Organic Acid Addition Before Fermentation on the Physicochemical and Sensory Properties of Cherry Wine.

Lack of acidity is the main reason for the spoilage of cherry wine, and for insufficient aroma and mouthfeel. In this study, the initial acidity of cherry purees was adjusted to 3.50, 4.

Use of traditional Chinese medicine bezoars and bezoar-containing preparations in hepatocarcinoma.

This manuscript used network pharmacology and experimental verification to analyze the anti-hepatocarcinoma mechanism of action of bezoars in traditional Chinese medicine (TCM), discovering that it can affect the immune cells within the tumor microenvironment and related pathways to produce inhibitory effects in liver cancer. In TCM, bezoars have a unique therapeutic advantage in the prevention and treatment of tumors. They play an anti-tumorigenic role by regulating the immune microenvironment through multi-component, multi-target and multi-pathway mechanisms.

Exploring the promising potential of alcohol extract from the aerial part of dill in ameliorating DSS-induced ulcerative colitis in mice.

Ethnopharmacological Relevance: Dill (Anethum graveolens L.) is a typical Uyghur medicine. It is traditionally used to treat sticky and stagnant dampness, hiccups and food stagnation, intestinal obstruction, and anorectal diseases.

Tensor dictionary-based heterogeneous transfer learning to study emotion-related gender differences in brain.

In practice, collecting auxiliary labeled data with same feature space from multiple domains is difficult. Thus, we focus on the heterogeneous transfer learning to address the problem of insufficient sample sizes in neuroimaging. Viewing subjects, time, and features as dimensions, brain activation and dynamic functional connectivity data can be treated as high-order heterogeneous data with heterogeneity arising from distinct feature space.

Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.

Purpose: To elucidate the genetic basis of primary angle-closure glaucoma (PACG) by identifying pathogenic tissue and critical tissue-specific variants.

Methods: The correlations among PACG susceptibility, axial length (AL), and anterior chamber depth (ACD) were evaluated using meta-analyses. Propensity score matching was utilized on 2161 participants from the Handan Eye Study to determine the risk factors independent of ACD and AL for PACG.