Publications by authors named "Qianzhuo Wang"
Background: Acute lung injury (ALI) is a life-threatening clinical syndrome with high mortality. Currently, the safe and effective therapies for ALI patients are still limited. Qingfei Huoxue decoction (QFHXD) is a hospital agreement prescription for treating pulmonary diseases and displays a remarkable efficacy.
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- Hepatic gluconeogenesis is important for regulating blood sugar levels and could be a target for treating type 2 diabetes, though its mechanisms are not fully known.
- This study identifies the deubiquitinase OTUB1 as a key player in gluconeogenesis, showing that its reduced levels are linked to higher blood sugar in diabetic mice and humans.
- The research reveals that OTUB1 interacts with and modifies YWHAB, a protein that inhibits gluconeogenesis, suggesting that OTUB1 could be a promising therapeutic target for managing type 2 diabetes.
The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has been steadily increasing, making it a leading chronic liver disease. MAFLD refers to a metabolic syndrome linked with type 2 diabetes mellitus, obesity. However, its pathophysiology is complex, there are currently no effective and approved medicines for therapy.
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