Diagnostic value of dual-layer spectral detector CT parameters for differentiating high- from low-grade bladder cancer.

Objectives: This study aimed to investigate the diagnostic value of spectral parameters of dual-layer spectral detector computed tomography (DLCT) in distinguishing between low- and high-grade bladder cancer (BCa).

Methods: This single-center retrospective study included pathologically confirmed BCa patients who underwent preoperative contrast-enhanced DLCT. Patients were divided into low- and high-grade groups based on pathology.

Symptomology of celiac artery compression: Classifying patients by the degree of celiac artery stenosis and secondary changes in collateral branches on computed tomography angiogram.

Purpose: This study aimed to analyze the correlation between the degree of celiac artery (CA) stenosis and the secondary changes in collateral branches in patients with CA compression (CAC) by CT and to classify patients by the combination of the two imaging features.

Methods: Patients with CAC identified by contrast-enhanced CT from January 2012 to December 2013 were retrospectively enrolled and divided into the symptomatic group and asymptomatic group. CA stenosis was categorized as mild, moderate, or severe, and collateral circulation as invisible, visible, or prominent.

Diagnostic performance of MRI in detecting prostate cancer in patients with prostate-specific antigen levels of 4-10 ng/mL: a systematic review and meta-analysis.

Objective: To investigate the diagnostic performance of MRI in detecting clinically significant prostate cancer (csPCa) and prostate cancer (PCa) in patients with prostate-specific antigen (PSA) levels of 4-10 ng/mL.

Methods: A computerized search of PubMed, Embase, Cochrane Library, Medline, and Web of Science was conducted from inception until October 31, 2023. We included articles on the use of MRI to detect csPCa or PCa at 4-10 ng/mL PSA.

Postbiotics in colorectal cancer: intervention mechanisms and perspectives.

Colorectal cancer (CRC) is a common malignancy affecting the gastrointestinal tract worldwide. The etiology and progression of CRC are related to factors such as environmental influences, dietary structure, and genetic susceptibility. Intestinal microbiota can influence the integrity of the intestinal mucosal barrier and modulate intestinal immunity by secreting various metabolites.

Exploring a simplified way to diagnose pelvic lipomatosis: prediction of pelvic fat volume using a single cross-sectional image.

Background: Pelvic lipomatosis (PL) is a rare disease characterized by the overgrowth of pelvic adipose tissue (AT). We investigated the relationships between areas of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) and pelvic fat volume (PFV), and analyzed the feasibility of diagnosing PL from a single cross-sectional image.

Methods: The study included 50 patients and 50 controls.

Effect of preoperative PI-RADS assessment on pathological outcomes in patients who underwent radical prostatectomy.

Objective: To assess the effect of preoperative MRI with standardized Prostate Imaging-Reporting and Data System (PI-RADS) assessment on pathological outcomes in prostate cancer (PCa) patients who underwent radical prostatectomy (RP).

Patients And Methods: This retrospective cohort study included patients who had undergone prostate MRI and subsequent RP for PCa between January 2017 and December 2022. The patients were divided into the PI-RADS group and the non-PI-RADS group according to evaluation scheme of presurgery MRI.

An MRI-based grading system for preoperative risk estimation of positive surgical margin after radical prostatectomy.

Objective: To construct a simplified grading system based on MRI features to predict positive surgical margin (PSM) after radical prostatectomy (RP).

Methods: Patients who had undergone prostate MRI followed by RP between January 2017 and January 2021 were retrospectively enrolled as the derivation group, and those between February 2021 and November 2022 were enrolled as the validation group. One radiologist evaluated tumor-related MRI features, including the capsule contact length (CCL) of lesions, frank extraprostatic extension (EPE), apex abutting, etc.

Daqing formula ameliorated allergic asthma and airway dysbacteriosis in mice challenged with ovalbumin and ampicillin.

Ethnopharmacological Relevance: Asthma is a chronic airway inflammatory disease that can lead to several complications caused by bacterial infections. However, recurrent attacks of the disease require long-term use of antibiotics, resulting in lung dysbiosis and poor outcomes. Daqing Formula (DQF) is a well-known herbal medicine in Pharmacopoeia of China, which is widely used for various stimuli-induced lower respiratory diseases, including asthma, bronchitis, and pneumonia.

The feasibility of contrast-enhanced CT to identify the adhesive renal venous tumor thrombus of renal cell carcinoma.

Objective: To identify adhesive renal venous tumor thrombus (RVTT) of renal cell carcinoma (RCC) by contrast-enhancement CT (CECT).

Materials And Methods: Our retrospective study included 53 patients who underwent preoperative CECT and pathologically confirmed RCC combined with RVTT. They were divided into two groups based on the intra-operative findings of RVTT adhesion to the venous wall, with 26 cases in the adhesive RVTT group (ARVTT) and 27 cases in the non-adhesive group (NRVTT).

USP33 promotes nonalcoholic fatty acid disease-associated fibrosis in gerbils via the c-myc signaling.

Nonalcoholic fatty acid disease (NAFLD) is a common complication of obesity associated with liver fibrosis. The underlying molecular mechanisms involved in the progression from normal to fibrosis remain unclear. Liver tissues from the liver fibrosis model identified the USP33 gene as a key gene in NAFLD-associated fibrosis.

Development and clinical utility analysis of a prostate zonal segmentation model on T2-weighted imaging: a multicenter study.

Objectives: To automatically segment prostate central gland (CG) and peripheral zone (PZ) on T2-weighted imaging using deep learning and assess the model's clinical utility by comparing it with a radiologist annotation and analyzing relevant influencing factors, especially the prostate zonal volume.

Methods: A 3D U-Net-based model was trained with 223 patients from one institution and tested using one internal testing group (n = 93) and two external testing datasets, including one public dataset (ETD, n = 141) and one private dataset from two centers (ETD, n = 59). The Dice similarity coefficients (DSCs), 95th Hausdorff distance (95HD), and average boundary distance (ABD) were calculated to evaluate the model's performance and further compared with a junior radiologist's performance in ETD.

Glucose determination behaviour of gold microspheres-electrodeposited carbon cloth flexible electrodes in neutral media.

Despite numerous advances in the field of nonenzymatic glucose detection, monitoring glucose in physiological applications is still a challenge and is mostly limited to electrode surface modification. This study proposes a simple method for electrodepositing cotton-like gold microspheres (CGMs) on a carbon cloth (CC) flexible electrode, with the potential for the functional supporting substrate to monitor glucose in a neutral environment. It was demonstrated that the voltammetric response of glucose oxidation increased with increases in glucose concentration in the 3D functional flexible substrate; moreover, the amperometric response of glucose oxidation increased over time.

In-situ growth of 3D rosette-like copper nanoparticles on carbon cloth for enhanced sensing of ammonia based on copper electrodissolution.

Copper is an attractive candidate for sensing ammonia. Here, an electrodissolution mechanism for measuring liquid-phase ammonia was developed via a novel three-dimensional rosette-like structure of copper nanoparticles (CuNPs) integrated onto carbon cloth (CuNPs/CC). A one-step hydrothermal synthetic procedure was employed to construct the metallic CuNPs with a stereo rosette-like pattern on flexible CC substrate.

Copper Nanowires Modified with Graphene Oxide Nanosheets for Simultaneous Voltammetric Determination of Ascorbic Acid, Dopamine and Acetaminophen.

Copper nanowires (Cu NWs) were modified with graphene oxide (GO) nanosheets to obtain a sensor for simultaneous voltammetric determination of ascorbic acid (AA), dopamine (DA) and acetaminophen (AC). The nanocomposite was obtained via sonication, and its structures were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). The electrochemical oxidation activity of the materials (placed on a glassy carbon electrode) was studied by cyclic voltammetry and differential pulse voltammetry.