SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration.

Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing excessive immune responses and maintaining immune balance. The effective migration of Treg cells is crucial for controlling the development and progression of inflammatory diseases. However, the mechanisms responsible for directing Treg cells into the inflammatory tissue remain incompletely elucidated.

Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging.

Aging is accompanied by homeostatic and functional dysregulation of multiple immune cell subsets. Group 3 innate lymphoid cells (ILC3s) constitute a heterogeneous cell population that plays pivotal roles in intestinal immunity. In this study, we found that ILC3s in aged mice exhibited dysregulated homeostasis and function, leading to bacterial and fungal infection susceptibility.

Advances in liquid biopsy-based markers in NSCLC.

Lung cancer is the second most-frequently occurring cancer and the leading cause of cancer-associated deaths worldwide. Non-small cell lung cancer (NSCLC), the most common type of lung cancer is often diagnosed in middle or advanced stages and have poor prognosis. Diagnosis of disease at an early stage is a key factor for improving prognosis and reducing mortality, whereas, the currently used diagnostic tools are not sufficiently sensitive for early-stage NSCLC.

The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection.

Innate lymphoid cells (ILCs) have been identified as a heterogeneous population of lymphocytes that mirrors the cytokine and transcriptional profile of adaptive T cells. The dynamic balance between key transcription factors determines the heterogeneity, plasticity, and functions of ILC subsets. The transcription factor ThPOK is highly conserved in biological evolution and exerts pivotal functions in the differentiation of T cells.

Label-free detection of biomarker alpha fetoprotein in serum by ssDNA aptamer functionalized magnetic nanoparticles.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the clinic, with the characteristics of occult onset, rapid progression, and high degree of malignancy. Alpha fetoprotein (AFP) is the most important biomarker of HCC, which is widely used in early screening, diagnosis, and prognosis observation. A series of immunoassays have been developed and frequently used in the detection of AFP based on antibodies.

The fluorescence and resonance Rayleigh scattering spectral study and analytical application of cerium (IV) and cefoperazone system.

In weak acidic medium of pH3.5-5.6, Ce(IV) can be reduced by cefoperazone (CPZ) to be Ce(III), which further combined with CPZ to form complex Ce(OH)3CPZ.

Resonance Rayleigh scattering spectra of Cu2+-adenine-WO4(2-) system and its analytical application.

In pH 6.6-7.2 Tris-HCl buffer, Cu(2+) could react with adenine (A) to form a 1:1 coordination cation [CuA](2+), which only resulted in minor change of the absorption spectrum.

Interaction of adenine with palladium chloride, determination of adenine via resonance Rayleigh scattering method.

In pH 1.7-3.5 acid medium, palladium chloride could react with adenine (A) to form a ternary complex of [PdCl(2)·A], which would self-aggregate to form uniformly dispersed nanoparticles-[PdCl(2)·A](n) with an average size of 42 nm through the squeezing effect of aqueous phase and van der Waals force.