Publications by authors named "Qianying He"
Article Synopsis
- - The study analyzes age-dependent changes in the brain proteins and their modifications in several mouse models of Alzheimer's disease (AD), focusing on how these models represent human AD complexities.
- - Results showed that commonly used mouse models only replicate about 30% of the protein changes seen in humans, but adding more genetic factors can increase this to 42%.
- - The research highlights inconsistencies between protein and gene expression in the 5xFAD model, indicating that amyloid plaque environments affect protein turnover, which could lead to new targets for AD treatment.
Introduction: Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide critical insights for personalized LOAD medicine.
Methods: Sex- and APOE-specific metabolic networks were constructed based on changes in 127 metabolites of 656 serum samples from the Alzheimer's Disease Neuroimaging Initiative cohort.
[The role of Toll-like receptor 4 in acute pancreatitis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2018
Toll-like receptors (TLRs) is a kind of pattern recognition receptor which widely exists on the cell membrane. It is a natural immune system component which can regulate the inflammatory response of the body participating in the signal transduction of cells and play an important role in the endogenous immune response. But the excessive inflammatory reaction initiated by TLRs can make the immune function of the body unbalanced and damage the function of many organs.
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