Publications by authors named "Qianyi Lai"
Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.
Front Cell Dev Biol
September 2024
Article Synopsis
- The study investigates the expression of MORC3, a transcriptional factor, in various cancers, particularly its connection to PD-L1 and the immune response against tumors.
- Results show that MORC3 is downregulated in several cancers, linking low levels of MORC3 to poor survival rates and increased expression of immune-related genes when MORC3 is knocked down.
- The research suggests that knocking down MORC3 not only raises PD-L1 levels but also activates genes related to cellular proliferation, indicating a complex role of MORC3 in cancer biology.