Pd-Catalyzed Aerobic Intermolecular 1,2-Diamination of Conjugated Dienes: Regio- and Chemoselective Synthesis of Piperazines and 2-Piperazinones.

Dinitrogen heterocycles are among the most important molecular structures, and the synthesis of these types of structures through intermolecular 1,2-diamination of olefins is a direct and efficient method. However, the types of nitrogen sources are mostly derived from ureas or arylamines, and nitrogen sources from aliphatic amines are still limited due to their distinct electronic and steric effects. Herein, we report a palladium-catalyzed aerobic intermolecular 1,2-diamination of conjugated dienes, using ethanediamine and α-amino amide derivatives as nitrogen sources respectively, for the synthesis of piperazines and 2-piperazinones in good yields (up to 95 %) and with high regio- and chemoselectivities.

Antitumor activity of tridentate pincer and related metal complexes.

Pincer complexes featuring tunable tridentate ligand frameworks are one of the most actively studied classes of metal-based complexes. Currently, growing attention is devoted to the cytotoxicity of pincer and related metal complexes. The antiproliferative activity of numerous pincer complexes has been reported.

Synthesis and application in asymmetric catalysis of P-stereogenic pincer-metal complexes.

P-stereogenic pincer-metal complexes are one of the most interesting pincer type organometallic compounds. Many kinds of this type of complexes were synthesized and used as catalysts in asymmetric catalysis. On the basis of our work in this field, this paper reports the recent progress in P-stereogenic pincer chemistry, including the synthesis of P-stereogenic pincer ligands, the synthesis of P-stereogenic pincer-metal complexes, and the achievements in P-stereogenic pincer-metal complex catalyzed asymmetric synthesis.