Targeting EGFR degradation by autophagosome degraders.

Several generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been developed for the treatment of non-small cell lung cancer (NSCLC) in clinic. However, emerging drug resistance mediated by new EGFR mutations or activations by pass, leads to malignant progression of NSCLC. Proteolysis targeting chimeras (PROTACs) have been utilized to overcome the drug resistance acquired by mutant EGFR, newly potent and selective degraders are still need to be developed for clinical applications.

Discovery of Novel Polycyclic Phloroglucinols via an Improved One-Pot Method.

In nature, polycyclic phloroglucinols are a class of compounds with considerable structural diversity and promising biological activities. Herein, we present an improved one-pot method that replaces the solution reaction conditions by mixing the reactants with column chromatography silica gel. Through this convenient, mild, slow, and diversity-oriented strategy, eight structurally unique polycyclic phloroglucinols were discovered, of which compound possesses a rare cage-like skeleton.

Nesting CoMo Binary Alloy Nanoparticles onto Molybdenum Oxide Nanosheet Arrays for Superior Hydrogen Evolution Reaction.

Transition-metal alloys have attracted a great deal of attention as an alternative to Pt-based catalysts for hydrogen evolution reaction (HER) in alkaline. Herein, a facile and convenient strategy to fabricate CoMo binary alloy nanoparticles nesting onto molybdenum oxide nanosheet arrays on nickel foam is developed. By modulating the annealing time and temperature, the CoMo alloy catalyst displays a superior HER performance.

Pd-Co nanoalloys nested on CuO nanosheets for efficient electrocatalytic N reduction and room-temperature Suzuki-Miyaura coupling reaction.

Due to their synergistic and tunable effects, bimetallic alloy systems have recently attracted considerable attention as superior catalysts. Herein, Pd-Co bimetallic alloy nanoparticles were uniformly deposited onto CuO nanosheet supports. This nanostructured catalyst was first shown to be an effective catalyst to convert N2 to NH3 in 0.