Publications by authors named "Qianxin He"
Background: Treatment as prevention evolved into the universal HIV test-and-treat (UTT) strategy, which entails testing to the general population and treatment to every people living with HIV. We investigated universal testing (UT) performance and its determinants in urban Ethiopia and explore magnitude of late diagnosis and its impact on disease stages.
Method: We used data from the Ethiopia Population Based HIV Impact assessment (EPHIA), conducted in 2017/2018 which was a cross-sectional and household-based study.
Background: Studies have shown high early mortality after initiation of highly active antiretroviral therapy (HAART). We examined change in three-year survival and predictors of mortality of patients initiating HAART in Ethiopia since 2007 to 2019.
Methods: A retrospective cohort study was conducted in 47 health facilities (HFs) using records of 11,013 adult patients initiating HAART from 2007 to 2019.
Evaluation of HIV-1 drug resistance among patients failing first-line antiretroviral therapy in Ethiopia.
J Glob Antimicrob Resist
September 2022
Objectives: The aim of this study was to evaluate HIV-1 drug resistance among patients failing first-line antiretroviral therapy in Ethiopia.
Methods: A total of 699 adults infected with HIV (aged ≥15 years) who failed first-line Antiretroviral Therapy (ART) were recruited between 2017 and 2019 from 63 ART-providing sites in Ethiopia. Treatment failure was defined as patients with two consecutive viral loads (VLs) ≥1000 copies/mL within six months of follow-up.
Aim: When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD) patients, PD has to be discontinued. Currently, there is no effective way to relieve PF. In this study, we aimed to determine whether miR-15a-5p is involved in PF and to determine the underlying mechanism.
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- Long-term peritoneal dialysis (PD) can lead to ultrafiltration failure (UFF) due to ongoing inflammation and fibrosis of the peritoneal tissues, with specific mechanisms still not fully understood.
- The study found that higher levels of vascular endothelial growth factor A (VEGFA) were linked to inflammation and fibrosis in the peritoneum of UFF patients, and HPMCs exposed to high glucose showed similar conditions.
- Furthermore, the microRNA miR-15a-5p was identified as significantly downregulated in patients, and its restoration was shown to inhibit VEGFA expression, leading to reduced inflammation and fibrosis, suggesting that targeting the miR-15a-5p/VEGFA pathway could help