Publications by authors named "Qianxi Ouyang"
Article Synopsis
- Penicamins A-L are 12 new diterpenes discovered in the fungus JSB-7212, featuring a unique tricyclic structure similar to valparane-type compounds.
- These compounds differ in their chemical configurations and oxidation levels, which were identified through advanced spectroscopic techniques and X-ray diffraction.
- Two of the Penicamins exhibited immunosuppressive effects on B cells and T cell proliferation, indicating potential therapeutic applications.
[Natural 5α-reductase inhibitors in treatment of benign prostatic hyperplasia].
Zhongguo Zhong Yao Za Zhi
February 2024
Article Synopsis
- Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, and its rates are on the rise in China, although the mechanisms behind it are still not fully understood.
- High levels of dihydrotestosterone (DHT), a hormone derived from testosterone through the action of the enzyme 5α-reductase, are linked to BPH, prompting interest in inhibiting this enzyme to reduce DHT levels.
- This review covers the distribution and characteristics of 5α-reductase, explores potential natural and traditional Chinese medicine inhibitors, discusses commonly used clinical inhibitors and their side effects, and presents animal models and detection methods for BPH research.
Article Synopsis
- Twelve new meroterpenoids were isolated from an endophytic fungus, XC1211, and their structures were determined using advanced spectroscopic techniques.
- The absolute configurations of certain compounds were established through single-crystal X-ray diffraction and electronic circular dichroism analysis.
- Two of the compounds showed strong inhibitory effects on the proliferation of LPS-induced B cells and reduced IL-6 secretion in a dose-dependent manner.
Eight unreported andrastin-type meroterpenoids, namely peniandrastins A-H (1-8), along with six known analogues (9-14), were isolated from the fermentation of a soil-derived fungus Penicillium sp.sb62. Their structures with absolute configurations were elucidated by detailed analyses of the spectroscopic data and single-crystal X-ray diffraction.
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- * Their structures were determined using advanced methods like spectroscopic analysis and single-crystal X-ray diffraction
- * Some of these compounds showed strong antiviral effects against influenza A (H1N1) and potent immunosuppressive activities on T and B cell proliferation, indicating potential therapeutic applications
Fourteen new [11]-chaetoglobosins (1-14), along with two known congeners, cytochalasins X and Y (15 and 16), were isolated from the cultures of an endophytic fungus Pseudeurotium bakeri P1-1-1. Their structures incorporating absolute configurations were elucidated based on the comprehensive analyses of one- and two-dimensional NMR data, HRESIMS spectrometry, chemical methods, and single-crystal X-ray diffraction analysis (Cu Kα). All isolates were evaluated for their cytotoxic activities and chaetopseudeurin M (1) displayed significant cytotoxic effects against seven human cancer cell lines, with IC values ranging from 5.
View Article and Find Full Text PDFEleven previously undescribed radicicol-type resorcylic acid lactones (RALs), namely ilyomycins A - K (1-9, 10a and 10b), were isolated and identified from the fermented rice culture of a soil-derived fungus, Ilyonectria sp. (strain sb65). Their gross structures were determined by extensive spectroscopic data, and the absolute configurations were elucidated by single-crystal X-ray diffraction, the modified Mosher's method, and Rh(OCOCF)-induced electronic circular dichroism (ICD) experiment.
View Article and Find Full Text PDFSeven undescribed cytochalasins, multirostratins K - Q (2: -8: ), together with one known analogue, cytochalasin Z3 (1: ), were isolated from the culture of XJ-2-1, an endophytic fungus obtained from the root of . Their structures with absolute configurations were determined by 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), single-crystal X-ray crystallography, and chemical methods. The structure of ascochalasin was revised from to by detailed analysis of the NMR data and by comparison with the data for 7: .
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