Publications by authors named "Qianquan Wan"
Hemolysin III drives neuroinvasion and meningitis while impacting desiccation resilience in .
Appl Environ Microbiol
March 2025
Unlabelled: is an emerging pathogen associated with severe neonatal diseases, including meningitis. Its ability to cross the blood-brain barrier (BBB) is critical for meningitis development, yet the underlying mechanisms remain unclear. This study investigates the role of Hemolysin III (Hly III), encoded by the , in neuroinvasion and environmental resilience.
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- Glioblastoma is the most common and aggressive brain tumor in adults, with cisplatin (DDP) being a common chemotherapy treatment for patients.
- A newly discovered circular RNA, circ_PTN, is highly expressed in GBM cells, but its role in DDP resistance was previously unclear.
- The study found that circ_PTN enhances DDP resistance in GBM cells by activating the PI3K/AKT pathway, suggesting that targeting circ_PTN could be a potential therapy to improve treatment outcomes for GBM patients.
Transplantation of human amniotic mesenchymal stem cells (hAM-MSCs) seems to be a promising strategy for the treatment of neurodegenerative disorders, including Alzheimer's disease (AD). However, the clinical therapeutic effects of hAM-MSCs and their mechanisms of action in AD remain to be determined. Here, we used amyloid precursor protein (APP) and presenilin1 (PS1) double-transgenic mice to evaluate the effects of hAM-MSC transplantation on AD-related neuropathology and cognitive dysfunction.
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