Background: Cyclophilin A (CyPA) is a potential mediator of inflammation. We assessed the predictive value of the first-trimester maternal serum CyPA concentrations for complicated pregnancy.
Methods: The first-trimester serum CyPA concentrations were quantified in 100 women with normal pregnancy and in 351 women with complicated pregnancy, including 102 pre-eclampsia women, 131 gestational hypertension (GH) women and 118 gestational diabetes mellitus (GDM) women.