Engineering band structures of two-dimensional materials with remote moiré ferroelectricity.

The stacking order and twist angle provide abundant opportunities for engineering band structures of two-dimensional materials, including the formation of moiré bands, flat bands, and topologically nontrivial bands. The inversion symmetry breaking in rhombohedral-stacked transitional metal dichalcogenides endows them with an interfacial ferroelectricity associated with an out-of-plane electric polarization. By utilizing twist angle as a knob to construct rhombohedral-stacked transitional metal dichalcogenides, antiferroelectric domain networks with alternating out-of-plane polarization can be generated.

Expression of CD4+CD25+CD127 regulatory T cells and cytokines in peripheral blood of patients with primary liver carcinoma.

To assess the clinical utility of the ratio of CD4+CD25+CD127 regulatory T cells (Tregs) in subjects at high risk of HCC, investigate the relationship between the percentage of Tregs and the expression of transforming growth factor (TGF)-β1 and interleukin (IL)-10 in patients with hepatocellular carcinoma before and after treatment. Peripheral venous blood was collected from patients with liver cancer before and after treatment. The proportion of CD4+CD25+CD127 Tregs was detected by flow cytometry.

Efficient production of human zona pellucida-3 in a prokaryotic expression system.

The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. We aimed to produce a recombinant ZP3 peptide using the Escherichia coli secretory system and apply it to a protein chip for detecting anti-ZP3 antibodies. The ZP3 gene was cloned into the pHOA downstream of the phoA promoter and transformed into E.

ICOS signal facilitates Foxp3 transcription to favor suppressive function of regulatory T cells.

Inducible costimulator (ICOS) plays an important role in the suppressive immunity mediated by regulatory T cells (Tregs), but the molecular regulation mechanism is not well known. Here we performed a study to explore the possible mechanism by which ICOS regulates the suppressive functions and survival of Tregs. This study showed that both the ICOS and CD28 signal could promote the survival of Tregs.

Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer.

ICOSTreg cells exert important immunosuppressive effects in tumor immunity. We adopt a combination approach of ICOSTreg cells depletion with tumor cell vaccine to evaluate anti-tumor immunity in mouse prostate cancer model. Streptavidin (SA)-mGM-CSF surface-modified RM-1 cells were prepared as the vaccine and the mouse subcutaneous prostate tumor model was used to evaluate the immunity.

[Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF].

Objective: To detect the roles of Livin and its relationship with bFGF in laryngeal squamous cell carcinoma (LSCC) through observing the expression of Livin and bFGF in laryngeal squamous cell carcinoma.

Method: Expression of Livin and bFGF in 41 cases of LSCC (11 cases with lymph node metastasis) and 20 cases of normal soft palate mucosa were detected by immunohistochemistry.

Result: Livin were positively detected in 29 (70.

[Bacteriological study on adult chronic sinusitis operated after endoscopic sinus surgery].

Objective: To explore the bacteria isolated from middle nasal meatus, maxillary sinus, ethmoid sinus and postoperative cavity of patients with chronic rhinosinusitis and their characteristics of antibiotic resistance.

Methods: Eighty-seven patients with chronic rhinosinusitis were operated on by ESS to obtain the pus specimen for bacterial culture and antibiotic susceptibility test, before and 1 month, 3 months and 6 months after operation.

Results: Totally 645 strains (26 species) of bacteria were detected in 464 specimens [total positive rate was 78.

[Correlation between the prognosis and the expression of survivin in surgical margins of laryngeal squamous cell carcinoma].

Objective: To investigate the relationship between the local recurrence and the five years survival rate and the expression of Survivin in surgical margins of laryngeal squamous cell carcinoma.

Method: Immunohistochemical technique (S-P) and image analysis were used to detect the expression of Survivin in the pathological negative margin specimen and primary site of cancer of 54 patients.

Result: (1) Expression of Survivin was detected in 66.