A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together.

Glioblastoma, a highly aggressive brain tumor, lacks effective treatment with low 5 year survival rates. Urgency for new therapies is evident. Mammalian targets of rapamycin (mTOR) and G1 to S phase transition 1 gene (GSPT1) are overexpressed in glioblastoma, regulating vital cellular functions.

Totally laparoscopic surgery for choledochal cysts with hand‑sewn Roux‑en‑Y reconstruction in a pediatric population.

Cyst excision and Roux-en-Y hepaticojejunostomy (RYHJ) is the standard treatment for choledochal cysts (CCs). In the present study, the results of totally laparoscopic surgery for CCs (TLCCs) in a pediatric population were evaluated. The clinical data of 28 children with CCs between June 2020 and June 2023 were retrospectively reviewed.

Degradation-Based Protein Profiling: A Case Study of Celastrol.

Natural products, while valuable for drug discovery, encounter limitations like uncertainty in targets and toxicity. As an important active ingredient in traditional Chinese medicine, celastrol exhibits a wide range of biological activities, yet its mechanism remains unclear. In this study, they introduced an innovative "Degradation-based protein profiling (DBPP)" strategy, which combined PROteolysis TArgeting Chimeras (PROTAC) technology with quantitative proteomics and Immunoprecipitation-Mass Spectrometry (IP-MS) techniques, to identify multiple targets of natural products using a toolbox of degraders.

Swarm intelligence based deep learning model via improved whale optimization algorithm and Bi-directional long short-term memory for fault diagnosis of chemical processes.

The chemical production process typically possesses complexity and high risks. Effective fault diagnosis is a key technology for ensuring the reliability and safety of chemical production processes. In this study, a comprehensive fault diagnosis method based on time-varying filtering empirical mode decomposition (TVF-EMD), kernel principal component analysis (KPCA), and an improved whale optimization algorithm (WOA) to optimize bi-directional long short-term memory (BiLSTM) is proposed.

Prenatal ultrasound diagnosis of congenital infantile fibrosarcoma and congenital hemangioma: Three case reports.

Background: Congenital infantile fibrosarcoma (CIF) and congenital hemangioma (CH) have similarities on prenatal ultrasound and are rare.

Case Summary: We report 3 cases of fetuses with superficial hypervascular tumors, confirmed by postnatal pathology as CIF (1 case) and CH (2 cases, including 1 in a twin fetus). In Case 1, a mass with a rich blood supply in the fetal axilla was discovered by prenatal ultrasound at 28+0 wk of gestation.

BRD4-targeting PROTAC as a unique tool to study biomolecular condensates.

Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically.

A Wireless Infrared Thermometry Device for Postoperative Flap Monitoring: Proof of Concept in Patients.

Background/need: Postoperative flap perfusion assessment methods still rely on the evaluation of traditional clinical indicators, which have the disadvantage of being subjective and burdensome.

Methodology: This study describes a self-designed infrared wireless thermometer for flap blood supply monitoring and evaluates its efficacy in the postoperative monitoring of 40 free flaps.

Device Description: The device consists of multiple temperature and humidity modules as well as a wireless module, which has the advantages of low cost and continuous remote monitoring.

A wireless infrared thermometry device for postoperative flap monitoring: Proof of concept in a porcine flap model.

The application of flap surgery is becoming more and more widespread with the development of microsurgical techniques. Currently, postoperative blood flow monitoring of flaps is still mainly assessed by medical staff for traditional clinical parameters, which has the disadvantage of being subjective and unable to monitor in real-time. This study describes a self-contained infrared wireless infrared thermometry device for flap blood supply monitoring and evaluates its effectiveness on eight porcine flap models.

Simultaneous achievement of defect passivation and carrier transport promotion by using emerald salt for methylammonium-free perovskite solar cells.

Defect passivation along with promoted charge transport is potentially an effective but seldom exploited strategy for high-performance perovskite solar cells (PSCs). Herein, the defect passivation and carrier transport improvement are simultaneously realized by introducing a conductive polymer (, emerald salt, ES) into the precursor solution of methylammonium (MA)-free perovskites. The interaction between ES and uncoordinated Pb reduces defect density to suppress the non-radiative recombination.

Association between SII and hepatic steatosis and liver fibrosis: A population-based study.

Background: The systemic immune-inflammation index (SII) is a novel marker of inflammation, and hepatic steatosis and fibrosis are associated with inflammation. This study aimed to investigate the possible relationship between SII and hepatic steatosis and fibrosis.

Methods: The datasets from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 were used in a cross-sectional investigation.

Cocktail therapy with prednisolone, vincristine and sirolimus for Kasabach‑Merritt phenomenon in 10 infants.

Kasabach-Merritt phenomenon (KMP) is a life-threatening condition caused by rare vascular tumors. To reduce drug resistance observed in monotherapy of KMP with prednisone, vincristine (VCR) or sirolimus, the present study evaluated the efficacy and safety of triad therapy in the treatment of KMP. A total of 10 KMP infants managed with prednisolone, VCR and sirolimus in The Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, China) between April 2017 and August 2021 were retrospectively reviewed.

Laparoscopic surgery of intra-abdominal lymphatic malformation in children.

Lymphatic malformation (LM) in the abdomen is uncommon in children, and the standard treatment is surgical excision. The present study aimed to evaluate the safety and efficacy of laparoscopic surgery of intra-abdominal LM in a pediatric population. The medical records of 10 children with intra-abdominal LM treated by laparoscopic resection from March 2017 to June 2021 in The Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, China) were retrospectively reviewed.

Hierarchical reinforcement learning for automatic disease diagnosis.

Motivation: Disease diagnosis-oriented dialog system models the interactive consultation procedure as the Markov decision process, and reinforcement learning algorithms are used to solve the problem. Existing approaches usually employ a flat policy structure that treat all symptoms and diseases equally for action making. This strategy works well in a simple scenario when the action space is small; however, its efficiency will be challenged in the real environment.

Microplastic contamination in seafood from Dongshan Bay in southeastern China and its health risk implication for human consumption.

Microplastic (MP) pollution has been a considerable concern due to its ubiquity in the environment and its potential to harm human health. Unfortunately, the exact levels of MP in various species of seafood species have not been established. It is also unclear whether or not consuming seafood contaminated with MPs directly jeopardizes human health.

High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20-59 Years of Age.

Background: Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between low-density lipoprotein cholesterol (LDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between LDL-C levels and BMD in persons aged 20 to 59.

Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018.

Background: Serum lipids are highly inheritable and play a major role in bone health. However, the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between HDL-C levels and BMD in persons aged 20-59.

Microplastics in a pelagic dolphinfish (Coryphaena hippurus) from the Eastern Pacific Ocean and the implications for fish health.

Microplastic pollution in fish is a growing concern worldwide due to its implication for human health. Microplastic contaminations and impacts were investigated in 15 wild-caught commercially important dolphinfish (Coryphaena hippurus L.) from the Eastern Pacific Ocean waters.

Microplastic pollution and ecological risk assessment in an estuarine environment: The Dongshan Bay of China.

Microplastic (MP) pollution has spurred a wide range of concerns due to its ubiquity and potential hazards to humans and ecosystems, yet studies on MP abundance, distribution, and ecological impacts on the small-scale local estuarine systems are insufficient. We conducted the first study of MP pollution in surface water of Dongshan Bay in southern China. A total of six water samples were collected using a Manta trawl (length = 3 m, width = 1 m, height = 0.

Riverine microplastic pollution matters: A case study in the Zhangjiang River of Southeastern China.

Microplastics have pulled the alarm for its far-reaching impacts in the environment and potential risks to human health. Here, we first investigated the microplastic pollution in the Zhangjiang River of southeastern China. Water samples were collected across a river catchment using bulk sampling method.

Novel Biomedical Functions of Surfactin A from in Wound Healing Promotion and Scar Inhibition.

Surfactin produced by is a powerful biosurfactant in food, cosmetics, and pesticide industries. However, its suitability in wound healing applications is uncertain. In this article, we determined the effects of surfactin A from on wound healing, angiogenesis, cell migration, inflammatory response, and scar formation.

Acceptance Prediction for Answers on Online Health-care Community.

Background: With the development of e-Health, it plays a more and more important role in predicting whether a doctor's answer can be accepted by a patient through online healthcare community. Unlike the previous work which focus mainly on the numerical feature, in our framework, we combine both numerical and textual information to predict the acceptance of answers. The textual information is composed of questions posted by the patients and answers posted by the doctors.

Environmental implications of microplastic pollution in the Northwestern Pacific Ocean.

Microplastics (MPs) contamination has been recognized as one of major threats to coastal marine environments. Although studies evidenced severe MPs contaminations to the Pacific Ocean, environmental implications of MPs concentrations, distributions, and characteristics have not been evaluated in sufficient detail. Here, we report on the distribution, abundance, and characteristics of MPs at the surface of the Northwestern Pacific Ocean, from which environmental implications are assessed.

Comparison of nighttime and daytime operation on outcomes of kidney transplant with deceased donors: a retrospective analysis.

Background: Kidney transplant is always emergent operations and frequently need to be performed at nighttime to reduce cold ischemia time (CIT). Previous studies have revealed that fatigue and sleep deprivation can result in adverse consequences of medical procedures. This study aimed to evaluate whether nighttime operation has adverse impact on kidney transplant.

Beneficial Effect of Moderately Increasing Hypothermic Machine Perfusion Pressure on Donor after Cardiac Death Renal Transplantation.

Background: Vascular resistance and flow rate during hypothermic machine perfusion (HMP) of kidneys is correlated with graft function. We aimed to determine the effects of increasing HMP pressure versus maintaining the initial pressure on kidney transplantation outcomes.

Methods: We retrospectively reviewed the data of 76 primary transplantation patients who received HMP-preserved kidneys from 48 donors after cardiac death between September 1, 2013, and August 31, 2015.