A novel anion replaced gemini surfactant: Investigation on the primary interaction between gemini surfactant and BSA.

Gemini surfactants (GS) could serve as the drug carrier agents for the delivery of macromolecules due to the excellent properties and tuneable structures. Little attention has been paid to the impact of counterion change on GS and the interaction between GS and protein. In this work, ibuprofen (Ibu) replaced quaternary ammonium ion GS (GS-Ibu) with the hydrophobic chain length of 8, 10, 12, 14 and 16 carbon atoms were prepared for the first-time using extraction technology.