Publications by authors named "Qianlin Cao"
Article Synopsis
- The study identifies RPRM as a protein that downregulates the ATM kinase, which is important for DNA damage repair, leading to increased sensitivity to radiation.
- RPRM moves to the cell nucleus after X-irradiation, where it interacts with ATM to promote its degradation through a process requiring phosphorylation by CDK4/6 and Importin-11.
- This regulatory mechanism shows that RPRM can enhance cellular sensitivity to radiation when overexpressed while its deficiency increases resistance to radiation-induced damage.
Space radiation cancer risk may be a potential obstacle for long-duration spaceflight. Among all types of cancer space radiation may induce, lung cancer has been estimated to be the largest potential risk. Although previous animal study has shown that Fe ions, the most important contributor to the total dose equivalent of space radiation, induced a higher incidence of lung tumorigenesis per dose than X-rays, the underlying mechanisms at cellular level remained unclear.
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