Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia.

FOXP3+ natural regulatory T cells (nTregs) promote resolution of inflammation and repair of epithelial damage following viral pneumonia-induced lung injury, thus representing a cellular therapy for patients with acute respiratory distress syndrome (ARDS). Whether in vitro induced Tregs (iTregs), which can be rapidly generated in substantial numbers from conventional T cells, also promote lung recovery is unknown. nTregs require specific DNA methylation patterns maintained by the epigenetic regulator, ubiquitin-like with PHD and RING finger domains 1 (UHRF1).

Distinct Control of histone H1 expression within the Histone Locus body by CRAMP1.

Proper histone gene expression is critical to cell viability and maintaining genomic integrity. Multiple histone genes organized into three genomic loci encode for replication coupled core and linker histones. Histone gene expression and transcript processing is orchestrated in the histone locus body (HLB) within the nucleus.

Diversity of Calonectria species from leaves and soils in diseased southern China Eucalyptus plantation.

Calonectria leaf blight (CLB) is one of the best-known diseases of Eucalyptus spp., particularly in Asia and South America. Recently, typical symptoms of leaf and shoot blight caused by Calonectria spp.

FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection.

FOXP3+ regulatory T (Treg) cells are necessary to coordinate resolution of lung inflammation and a return to homeostasis after respiratory viral infections, but the specific molecular requirements for these functions and the cell types governed by Treg cells remain unclear. This question holds significance as clinical trials of Treg cell transfer therapy for respiratory viral infection are being planned and executed. Here, we report causal experiments in mice determining that Treg cells are necessary to control the numbers of activated CD8+ T cells during recovery from influenza infection.

Ezrin's role in gastric cancer progression: Implications for immune microenvironment modulation and therapeutic potential.

At present, surgical resection is the most effective method for the treatment of gastric cancer. However, death caused by inoperable metastasis is still very common, despite research in this area. The mechanisms underlying the occurrence, development, and metastasis of gastric cancer are not fully understood.

AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress.

CD4+FOXP3+ regulatory T (Treg) cells maintain self-tolerance, suppress the immune response to cancer, and protect against tissue injury in the lung and other organs. Treg cells require mitochondrial metabolism to exert their function, but how Treg cells adapt their metabolic programs to sustain and optimize their function during an immune response occurring in a metabolically stressed microenvironment remains unclear. Here, we tested whether Treg cells require the energy homeostasis-maintaining enzyme AMP-activated protein kinase (AMPK) to adapt to metabolically aberrant microenvironments caused by malignancy or lung injury, finding that AMPK is dispensable for Treg cell immune-homeostatic function but is necessary for full Treg cell function in B16 melanoma tumors and during acute lung injury caused by influenza virus pneumonia.

: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster.

The biological role of the repetitive DNA sequences in the human genome remains an outstanding question. Recent long-read human genome assemblies have allowed us to identify a function for one of these repetitive regions. We have uncovered a tandem array of conserved primate-specific retrogenes encoding the protein Elongin A3 (ELOA3), a homolog of the RNA polymerase II (RNAPII) elongation factor Elongin A (ELOA).

Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study.

Objective: This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders.

Methods: A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination centre of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, high-density lipoprotein-cholesterol, cholesterol, low-density lipoprotein-cholesterol, and fasting plasma glucose.

IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM.

Introduction: The immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in glioblastoma (GBM). Transgenic expression of IL15 is one attractive strategy to modulate the TME. However, at present, it is unclear if IL15 could be used to directly target myeloid-derived suppressor cells (MDSCs), a major cellular component of the GBM TME.

Effect of minimally invasive repair of pectus excavatum on postoperative chest flatness, cardiopulmonary function, and bone metabolism indexes in children at different ages.

Objective: To observe the effects of minimally invasive surgical repair of pectus excavatum (NUSS) on the degree of chest flatness, cardiopulmonary function, and bone metabolism indexes in children of various age groups.

Methods: In this retrospective study, 62 children with pectus excavatum admitted to our hospital were divided into two groups: group A (3-12 years old) and group B (>12 years old), with 31 cases in each group. All of them were treated with NUSS.

Comparison of Hyphal Fragments and Spores to Evaluate the Pathogenicity of the Leaf and Shoot Pathogen .

The genus includes many aggressive plant-pathogenic species with a worldwide distribution. Calonectria leaf blight is one of the most prominent diseases of trees in Southeast Asian and South American plantations. Inoculation trials to evaluate pathogenicity of spp.

Scene-Specialized Multitarget Detector with an SMC-PHD Filter and a YOLO Network.

You only look once (YOLO) is one of the most efficient target detection networks. However, the performance of the YOLO network decreases significantly when the variation between the training data and the real data is large. To automatically customize the YOLO network, we suggest a novel transfer learning algorithm with the sequential Monte Carlo probability hypothesis density (SMC-PHD) filter and Gaussian mixture probability hypothesis density (GM-PHD) filter.

Novel species of isolated from soil near plantations in southern China.

species are soil-borne and widely distributed in tropical and subtropical regions around the world. The species in this genus include many important plant pathogens that cause serious diseases to economically important crops and forest trees. Previous research results indicated that the leaf blight and cutting rot caused by species caused big losses to the industry in southern China, and large number of species identified in China have been collected from soil in plantations.

Phylogeny and Pathogenicity of Celoporthe Species from Plantation Eucalyptus in Southern China.

The family of Cryphonectriaceae (Diaporthales) includes many important tree pathogens, such as those that cause severe cankers on Eucalyptus trees. Recently, stem canker and cracked bark were observed on 8-year-old Eucalyptus grandis × E. urophylla trees in a plantation in southern China.

species isolated from plantations and nurseries in South China.

Diseases caused by species of () represent a serious threat to the growth and sustainability of plantations in China. Symptoms caused by these fungi mainly include leaf blight on trees in plantations and rotting of stems and leaves in nurseries. Extensive surveys have recently been conducted where species were collected in plantations and nurseries in the FuJian, GuangDong, GuangXi, and YunNan Provinces of South China.

Risk analysis and outcomes of bronchopulmonary sequestrations.

Background: Researched and discussed the risks and outcomes of bronchopulmonary sequestrations, especially the intralobar type.

Methods: A retrospective review of our experiences with bronchopulmonary sequestrations from January 2012 to April 2015 is reported. The present study researched and discusses the risks and outcomes of bronchopulmonary sequestrations, especially the intralobar type, compared with other types of bronchopulmonary sequestrations in symptoms, surgery, pathology, and excretion.

[Dynamics of carbon and nitrogen storage of Cupressus chengiana plantations in the arid valley of Minjiang River, Southwest China].

The carbon and nitrogen storage and distribution patterns of Cupressus chengiana plantation ecosystems with different stand ages in the arid valley of Minjiang River were studied. The results showed that carbon contents in different organs of C. chengiana were relatively stable, while nitrogen contents were closely related to different organs, and soil organic carbon and nitrogen contents increased with the stand age.

Highly aligned dense carbon nanotube sheets induced by multiple stretching and pressing.

The CNT sheet fabricated by the floating catalyst chemical vapor deposition (CVD) method has attracted great attention due to its easy fabrication process and promising mass production at low cost. However, the randomly oriented CNT sheet with a loose stacking density shows relatively poor mechanical properties. In this work, a highly aligned dense CNT sheet was successfully fabricated by a simple process of two-time stretching and pressing of a multilayered CVD-grown CNT sheet.